| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To assess influence of periodontal disease-causing bacteria infection on peritoneal dialysis (PD), we investigated the relationship between periodontal pathogenic bacterial infection an the tissue damage associated with PD were examined. We tried to detect periodontitis causative bacteria in peritoneal dialysis from patients. However, P. gingivalis which is a periodontitis causing bacterium could not be detected.
Next, rat C5a and C5adesArg were prepared in order to clarify in the model animals that bacterial infection and elevation of the concentration of anaphylatoxin directly exacerbate the inflammatory response. When C5a and C5adesArg were administered to rats, a marked inflammatory response was not detected with anaphylatoxin alone. As contrast, C5a administration with low concentration of LPS induced a strong inflammatory response. Interestingly, C5adesArg, that is inactivated C5a also enhanced inflammatory response when pre-administration of low concentration LPS.
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