Analysis of the Mechanism of Cardiovascular Disease using periodontopathic bacteria
| Project/Area Number |
26462850
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pathobiological dentistry/Dental radiology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
Fujino Akane 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20405327)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
大迫 文重 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10398406)
山本 俊郎 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40347472)
喜多 正和 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60153087)
金村 成智 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (70204542)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 歯周病原菌 / 心血管系疾患 / マウス菌血症モデル |
|---|
| Outline of Final Research Achievements |
Gene expression of inflammatory cytokines increased with time in human coronary artery endothelial cells when they were stimulated with lipopolysaccharide, an endotoxin derived from periodontal pathogens. Similarly, gene expression of cardiac inflammatory cytokines increased significantly compared with the control in a model of bacteremia. However, the gene expression of inflammatory cytokines decreased significantly after 48 hours. Instead, the proportion of bone marrow-derived immune cells increased.
These findings suggest that periodontal pathogens cause inflammation in human coronary artery endothelial cells and cardiac tissue, and that bone marrow-derived immune cells may act to reduce the inflammation.
|
Report
(4 results)
Research Products
(1 results)
