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The mechanism of metal allergy construction by a transcription factor controlling immunocompetent cells and a surface reforming effect.

Research Project

Project/Area Number 26462851
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionEhime Prefectural University of Health Science

Principal Investigator

TAMAUCHI HIDEKAZU  愛媛県立医療技術大学, 保健科学部, 教授(移行) (60188414)

Co-Investigator(Kenkyū-buntansha) 小茂鳥 潤  慶應義塾大学, 理工学部(矢上), 教授 (30225586)
Co-Investigator(Renkei-kenkyūsha) YAMASHITA KATSUMASA  愛媛大学, 大学院・医学系研究科, 教授 (00311605)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsニッケル / アレルギー / 転写因子 / Th1 / Th2 / NKT細胞 / 金属アレルギー / GATA-3 / Gfi1 / ノックアウトマウス / トランスジェニックマウス / サイトカイン
Outline of Final Research Achievements

It suggested that the GATA-3 transcription factor is associated with not only the Th2 type immune response but also the differentiation of NKT cells.The Th2 cells find that they are associated with the sthenia of the response in early period of metal allergy.We made clear that NKT cells functioned for an allergy to metal response restrainingly this time. Also, in the allergy to metal instruction study using the Gfi-1 genetic effect mouse, and determined sthenia of the allergic reaction and determined that pro-an in vitro experiment, an IFN-γ production was enhanced remarkably. Rather than these, it was suggested that the clinical condition of the allergy to metal was built as well as a Th1 type cells in the mechanism of pathogenesis of the allergy to metal by the reciprocal effects of the 2 type cells and NKT cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Change of absorptivity with glycoprotein on the Ti-Ta-Sn alloy by UV irradiation.2017

    • Author(s)
      Kiyama Koshiro, Miki Masahito, Tamauchi Hidekazu, Morita Msafumi
    • Journal Title

      Material Science and Technology of Japan.

      Volume: 54 Pages: 80-82

    • NAID

      40021176807

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory function of NKT cells during early induction phase of nickel allergy2016

    • Author(s)
      Hironori Okuno, Masahi Satoh, Emiko Takeuchi, Koji Eshima, Masazumi Terashima, Jun Komotori, Sonoko Habu, Hidekazu Tamauchi, Kazuya Iwabuchi
    • Journal Title

      Immunobiology

      Volume: 221 Pages: 833-838

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells2016

    • Author(s)
      Junpei Suzuki, Saho Maruyama, Hidekazu Tamauchi, Makoto Kuwahara, Mika Horiuchi, Masumi Mizuki, Mizuki Ochi, Tatsuya Sawasaki, Jinfang Zhu, Masaki Yasukawa, Masakatsu Yamashita
    • Journal Title

      Immunology

      Volume: 147 Issue: 4 Pages: 476-487

    • DOI

      10.1111/imm.12580

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 転写制御因子Gfi1はTh1細胞分化とTh1型アレルギーを負に制御する2015

    • Author(s)
      堀内美香, 鈴木淳平, 水木 真純, 丸山砂穂, 玉内秀一, 安川正貴, 山下政克
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      東京(品川プリンスホテル)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Gfi negatively regulates murine NIckel allergy through inihibition og Th1 differentiation2014

    • Author(s)
      MARUYAMA SAHO, MIAUKI MASUMI, KUWAHARA MAKOTO, ZHU JINFANG, TAMAUCHI HIDEKAZU, YAMASHITA MASAKATSU
    • Organizer
      Japanese Society for Immunology (JSI)
    • Place of Presentation
      Koyoto International Conference Center
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 生体材料とニッケルアレルギー2014

    • Author(s)
      玉内秀一
    • Organizer
      SMAシンポジウム2014
    • Place of Presentation
      アクロス福岡
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 転写抑制因子Gfi-1ノックアウトマウスを用いた金属アレルギーの発症機序 ーGfi-1は、Th1細胞分化を負に制御するー2014

    • Author(s)
      水木真帆、丸山砂穂、玉内秀一、山下政克
    • Organizer
      文部科学省GP/基礎GP 医学・医療の高度化の基礎を担う基礎研究医の陽性 第15回医科学研究発表会
    • Place of Presentation
      愛媛大学医学部
    • Year and Date
      2014-09-18 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Book] 先進機能材料・先進生体材料としての形状記憶合金の新しい用途開発2014

    • Author(s)
      玉内秀一
    • Total Pages
      58
    • Publisher
      一般社団法人 形状記憶合金協会 (ASMA)
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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