Genome-wide analysis of epigenetics in the sialadenitis from Sjogren's syndrome
Project/Area Number |
26462852
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Health Sciences University of Hokkaido |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
太田 亨 北海道医療大学, 個体差健康科学研究所, 教授 (10223835)
田隈 泰信 北海道医療大学, 歯学部, 教授 (40095336)
齊藤 正人 北海道医療大学, 歯学部, 教授 (50337036)
斎藤 一郎 鶴見大学, 歯学部, 教授 (60147634)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | シェーグレン症候群 / エピジェネティクス / DNAメチル化 / エピジェネティック / 炎症性疾患 / 口腔 |
Outline of Final Research Achievements |
We performed Genome-wide analysis of epigenetics in the sialadenitis from Sjogren's syndrome. The hypermethylations of E-cadherin and β-catenin; epithelium adhesion connection genes and MGMT; DNA repair enzyme gene were analyzed. The hypermethylation of E-cadherin, β-catenin and MGMT may be involved in the pathogenesis of Sjogren's syndrome. The hypermethylations of these genes may be therapeutic target for Sjogren's syndrome.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] HBD-2 is downregulated in oral carcinoma cells by DNA hypermethylation, and increased expression of hBD-2 by DNA demethylation and gene transfection inhibits cell proliferation and invasion.2014
Author(s)
Kamino Y, Kurashige Y, Uehara O, Sato J, Nishimura M, Yoshida K, Arakawa T, Nagayasu H, Saitoh M, Abiko Y.
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Journal Title
Oncol Rep.
Volume: 32
Issue: 2
Pages: 462-468
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] High frequency of DNA hypermethylation in lichen planus2016
Author(s)
Takatoshi Chujo, Bhoj Raj Adhikari, Tetsuro Morikawa, Fumiya Harada, Koki Yoshida, Jun Sato, Michiko Nishimura, Kenichi Matsuzaka, Takashi Inoue, Yoshihiro Abiko
Organizer
The 93st General Session & Exhibition of the IADR
Place of Presentation
韓国、ソウル
Year and Date
2016-06-22
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[Presentation] Hypermethylation of inflammation-related Genes in HPDL Cells Stimulated With LPS.2014
Author(s)
R.Takai, F.HARADA, M.UTSUNOMIYA, T.CHUJO, O.UEHARA, K.YOSHIDA, J.SATO,M.NISHIMURA, I.CHIBA, and Y.ABIKO
Organizer
IADR/PER CONGRESS 2014
Place of Presentation
Valamar Hotels, Dubrovnik, Croatia
Year and Date
2014-09-12
Related Report
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[Presentation] Hypermathylation of 12-collagen ando Fibronection in HPDL Cells by LPS2014
Author(s)
Y.ABIKO, R.TAKAI, O.UEHARA, F.HARADA, M.UTSUNOMIYA, T.CHUJO, K.YOSHIDA, J.SATO, M.NISHIMURA, and M.SAITOH
Organizer
IADR/PER CONGRESS 2014
Place of Presentation
Valamar Hotels, Dubrovnik, Croatia
Year and Date
2014-09-12
Related Report
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