| Project/Area Number |
26462852
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
太田 亨 北海道医療大学, 個体差健康科学研究所, 教授 (10223835)
田隈 泰信 北海道医療大学, 歯学部, 教授 (40095336)
齊藤 正人 北海道医療大学, 歯学部, 教授 (50337036)
斎藤 一郎 鶴見大学, 歯学部, 教授 (60147634)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | シェーグレン症候群 / エピジェネティクス / DNAメチル化 / エピジェネティック / 炎症性疾患 / 口腔 |
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| Outline of Final Research Achievements |
We performed Genome-wide analysis of epigenetics in the sialadenitis from Sjogren's syndrome. The hypermethylations of E-cadherin and β-catenin; epithelium adhesion connection genes and MGMT; DNA repair enzyme gene were analyzed. The hypermethylation of E-cadherin, β-catenin and MGMT may be involved in the pathogenesis of Sjogren's syndrome. The hypermethylations of these genes may be therapeutic target for Sjogren's syndrome.
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