| Project/Area Number |
26462853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | エクソソーム / microRNA / 細胞外小胞 / 破骨細胞 / 歯周病 / ナノ粒子 / バイオマーカー / リキッドバイオプシー / 骨吸収 / 炎症性サイトカイン / マクロファージ / Exosomes / Extracellular Vesicles / Osteoclasts / Bone / Periodontal Disease |
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| Outline of Final Research Achievements |
Periodontal disease is an inflammatory disease caused by bacterial infection of tooth-supporting structures, which results in the destruction of alveolar bone. Exosomes are nano-sized particles, which contain microRNAs, mRNAs, proteins, and lipids. Recent studies have begun to uncover that exosomes play a role in cell-to-cell communication by the transfer of microRNAs to recipient cells. Focusing on alveolar bone loss in periodontal disease, this study aims at revealing functions of microRNAs in exosomes. TNF-α promoted the secretion of exosomes by macrophages, and it altered the expression profile of microRNAs in exosomes. Periodontal ligament fibroblasts abundantly secreted exosomes, which contain small RNAs.
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