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Mechanism of multidrug resistance caused after the treatment targeting CD44, and the strategy for overcoming the resistance in head and neck squamous cell carcinoma.

Research Project

Project/Area Number 26462854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionAomori University (2015-2016)
Meikai University (2014)

Principal Investigator

OHKOSHI Emika  青森大学, 薬学部, 准教授 (10287667)

Co-Investigator(Kenkyū-buntansha) 梅村 直己  朝日大学, 歯学部, 助教 (80609107)
Co-Investigator(Renkei-kenkyūsha) TOMOMURA Mineko  明海大学, 総合教育セ, 教授 (30217559)
SUGIMOTO Masahiro  慶應義塾大学, 先端生命科学研, 教授 (30458963)
Research Collaborator GOTO Masuo  University of North Carolina at Chapel Hill, Pharmacy Research Assistant Professor
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords薬剤耐性 / がん幹細胞
Outline of Final Research Achievements

Many studies have demonstrated that a variety of human malignancies, including head and neck squamous cell carcinoma (HNSCC), contain subpopulations of cells called cancer stem-like cells (CSCs) that exhibit stem cell-like properties, such as self-renewal and tumor-initiating capabilities. CD44 is a marker of cancer stem cells in HNSCC, and CD44 expression is related to prognosis in cancer patients. The resistance of CSCs to conventional chemoradiotherapy may involve enhanced DNA damage repair pathways and alterations in cell cycle kinetics. Chk1 mediates S and G2 arrests. Our findings suggest that CD44 plays a role in enhancing the DNA damage response coordinated by Chk1. As part of a study of acquired multidrug resistance, then HSC-3 was grown in gradually increasing cisplatin concentrations and selected a resistant subline denote R HSC-3. R HSC-3 showed cross-resistance to several anticancer agents. The multidrug transporter, ABCG2, and CD44 were upregulated in R HSC-3 cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Presentation (8 results)

  • [Journal Article] Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells2017

    • Author(s)
      Emika Ohkoshi and Naoki Umemura
    • Journal Title

      INTERNATIONAL JOURNAL OF ONCOLOGY

      Volume: 50 Issue: 2 Pages: 387-395

    • DOI

      10.3892/ijo.2016.3821

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Metastasized murine oral squamous cell carcinoma cells induce intratumoral polymorphonuclear myeloid derived suppressor cells2017

    • Author(s)
      Shigeki Sumi, Naoki Umemura, Eiji Takayama, Emika Ohkoshi, Makoto Adachi, Masako Mizuno-Kamiya, Toshihiro Inagaki, Harumi Kawaki, Shinichiro Sumitomo and Nobuo Kondoh
    • Journal Title

      ONCOLOGY REPORTS

      Volume: 37 Issue: 5 Pages: 2897-2904

    • DOI

      10.3892/or.2017.5575

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD442016

    • Author(s)
      Naoki Umemura, Emika Ohkoshi, Masamichi Tajima, Hirotaka Kikuchi, Tadashi Katayama and Hiroshi Sakagami
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 7 Issue: 1 Pages: 135-147

    • DOI

      10.1186/s13287-016-0399-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Triethylated chromones with substituted naphthalenes as tubulin inhibitors2016

    • Author(s)
      Kyoko Nakagawa-Goto, Yukako Taniguchi, Yurie Watanabe, Akifumi Oda, Emika Ohkoshi, Ernest Hamel, Kuo-Hsiung Lee, Masuo Goto
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 24 Issue: 22 Pages: 6048-6057

    • DOI

      10.1016/j.bmc.2016.09.062

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 青森県産食品素材に関する研究-干菊の成分研究第3報-2017

    • Author(s)
      本木雅大、村上浩一、大越絵実加、梅村直己、齋藤俊昭、上田條二
    • Organizer
      日本薬学会137年会
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌におけるシスプラチン耐性株の機能解析2017

    • Author(s)
      村上 浩一、本木 雅大、大越 絵実加、梅村 直己、上田 條二
    • Organizer
      日本薬学会137年会
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
  • [Presentation] 薬学生によるセルフメディケーション発信の有用性-健康意識向上に対する地域 医療支援-2017

    • Author(s)
      井沼 道子、相馬 理佐、邉見 華菜恵、佐々木 智江、澤田 陽生、中村 祐介、村井 収平、 村上 浩一、本木 雅大、竹林 優佳、小笠原 大樹、大越 絵実加、佐藤 芳久、三浦 裕也、上田 條二
    • Organizer
      日本薬学会137年会
    • Place of Presentation
      仙台
    • Related Report
      2016 Annual Research Report
  • [Presentation] 青森県産食品素材に関する研究-干菊の成分研究第2報-2016

    • Author(s)
      本木雅大
    • Organizer
      日本薬学会136年会(横浜)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌のCD44過剰発現は細胞周期G2/M期のDNA修復シグナル経路によるmitotic catastropheに抵抗する2016

    • Author(s)
      村上浩一
    • Organizer
      日本薬学会136年会(横浜)
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 青森県産食品素材に関する研究-干菊の成分研究-2015

    • Author(s)
      村上浩一
    • Organizer
      第54回日本薬学会東北支部大会
    • Place of Presentation
      岩手医科大学
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Baicalein, a major ingredient of herbal medicines, induced inadequate expression of CD44 that attenuated DNA damage-induced apoptosis in human head and neck squamous cell carcinoma.2015

    • Author(s)
      大越絵実加
    • Organizer
      日本薬理学会88年会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌におけるberberineのNotch-1のダウンレギュレーション2014

    • Author(s)
      大越絵実加
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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