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Analysis of immune responses in oral epithelial dysplasia

Research Project

Project/Area Number 26462857
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTokyo Medical University

Principal Investigator

Chikazu Daichi  東京医科大学, 医学部, 教授 (30343122)

Co-Investigator(Kenkyū-buntansha) 里見 貴史  東京医科大学, 医学部, 講師 (70276921)
長尾 俊孝  東京医科大学, 医学部, 主任教授 (90276709)
Research Collaborator Enomoto Ai  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords上皮性異形成 / 口腔扁平苔癬 / 口腔粘膜 / 異形成 / 扁平上皮癌 / 細胞性免疫反応
Outline of Final Research Achievements

We conducted a study among patients with epithelial dysplasia of the tongue. The subjects were divided into two groups: high grade group and low grade group, with both undergoing immunostaining of any immunocompetent cells, such as cytotoxic T cells. We examined the relationship between the number of lymphocytes infiltrating the intraepithelial and subepithelial connective tissues and the clinical course. The study also included subjects with oral lichen planus (OLP) in order to compare dysplasia lesions and benign inflammatory lesions.
The number of lymphocytes intraepithelially infiltrating (CD8, CD4 cells) tended to be larger in the patients with low grade compared to those with high grade. Among those who were found to have changed from low grade to high grade at the follow-up, there was a decreasing tendency in the number of lymphocytes intraepithelially infiltrating. There was no significant difference from OLP in terms of the number of lymphocytes intraepithelially infiltrating.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2018 2016 2015 2012

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Intraepithelial CD8+ lymphocytes as a predictive diagnostic biomarker for the remission of oral lichen planus2018

    • Author(s)
      Enomoto Ai、Sato Eiichi、Yasuda Takashi、Isomura Tatsuya、Nagao Toshitaka、Chikazu Daichi
    • Journal Title

      Human Pathology

      Volume: 74 Pages: 43-53

    • DOI

      10.1016/j.humpath.2017.12.008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toll-like receptor 2 activation implicated in oral squamous cell carcinoma development.2018

    • Author(s)
      Ikehata N, Takanashi M, Satomi T, Watanabe M, Hasegawa O, Kono M, Enomoto A, Chikazu D, Kuroda M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 495 Issue: 3 Pages: 2227-2234

    • DOI

      10.1016/j.bbrc.2017.12.098

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A randomized trial to identify the most effective dose of remifentanil during Le fort I osteotomy.2015

    • Author(s)
      Harutsugi Abukawa, Akira Matsuo, Masato Watanabe, Michihide Kono, Takafumi Satomi, and Daichi Chikazu.
    • Journal Title

      J Oral Maxillofac Surg

      Volume: 73(6) Issue: 6 Pages: 1073-1077

    • DOI

      10.1016/j.joms.2014.12.035

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of dental implants as a risk factor for the development of bisphosphonate-related osteonecrosis of the jaw in brest cancer patients.2015

    • Author(s)
      Akira Matsuo, Hayato Hamada, Hidetoshi Takahashi, Ayako Okamoto, Hiroshi Kaisei, and Daichi Chikazu.
    • Journal Title

      Odontology

      Volume: 9 Issue: 3 Pages: 1-9

    • DOI

      10.1007/s10266-015-0207-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 下顎歯肉に転移した肺原発多形癌の1例.2015

    • Author(s)
      立花絵理子、山口洋平、立花哲也、山科光正、近津大地
    • Journal Title

      日本口腔外科学会雑誌,

      Volume: 61(9) Pages: 458-462

    • NAID

      130005129604

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] ナンセンス変異によるPTCH1遺伝子を伴った母斑基底細胞癌症候群の1例.2015

    • Author(s)
      浜田勇人、古賀陽子、虻川東嗣、河野通秀、藤川 考、近津大地
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 61(2) Pages: 120-124

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 若年性のびまん性下顎骨骨髄炎にパミドロネートが著効した1例.2015

    • Author(s)
      河野通秀、渡辺正人、浜田勇人、藤川 考、里見貴史、近津大地
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 61(7)

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chondrosarcoma of the maxilla extending to the pterygomandibular space : A case report and review of the literature2012

    • Author(s)
      Satomi T, Kaneko T, Abukawa, H Hasegawa O, Watanabe M, Matsubayashi J, Nagao T, Chiba H, Chikazu D
    • Journal Title

      J Maxillofac Oral Surg

      Volume: 14 Issue: S1 Pages: 133-137

    • DOI

      10.1007/s12663-012-0367-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Intraepithelial CD8 lymphocyte infiltration as a predictive biomarker of oral lichen planus2016

    • Author(s)
      榎本愛、佐藤永一、長尾俊孝、近津大地
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      宮城、仙台国際センター
    • Year and Date
      2016-05-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of neurosphere generation from human dental pulp stem cells in completery serum-free condition2015

    • Author(s)
      Yoko Kawase-Koga, Yasuyuki Fujii, and Daichi Chikazu
    • Organizer
      10th Annual Translation Stem Cell Research Conference.
    • Place of Presentation
      New York, USA
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Highly efficient and stable culture for human dental pulp stem cells in serum-free condition2015

    • Author(s)
      Yasuyuki Fujii, Yoko Kawase-Koga, and Daichi Chikazu
    • Organizer
      10th Annual Translation Stem Cell Research Conference.
    • Place of Presentation
      New York, USA
    • Year and Date
      2015-10-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A randomized trial to identify the most effective dose of dexamethasone after bilateral sagittal split osteotomies2015

    • Author(s)
      Harutsugu Abukawa, Yoko Koga, Michihide Kono, Takafumi Satomi, and Daichi Chikazu
    • Organizer
      22st International Conference on Oral and Maxillofacial Surgery.
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of red light-emitting diode irradiation on the proliferation and differentiation of preosteoblastic MC3T3-E1 cells2015

    • Author(s)
      Hiroaki Suzuki, Tomoko Asai, Midori Kitayama, Kousuke Matsumoto, Akira Kimoto, Manabu Shigeoka, Daichi Chikazu, and Takahide Komori:
    • Organizer
      22st International Conference on Oral and Maxillofacial Surgery.
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔扁平苔癬における臨床像と細胞傷害性免疫反応の関連2015

    • Author(s)
      榎本 愛、安田卓史、山科光正、近津大地
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔癌において組織学的悪性度により評価した上皮間葉移行に関する免疫組織化学的検討2015

    • Author(s)
      渡辺正人、榎本 愛、河野通秀、長谷川温、虻川東嗣、里見貴史、近津大地
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 粘表皮癌6例の臨床的検討2015

    • Author(s)
      長谷川温、里見貴史、河野通秀、渡辺正人、虻川東嗣、榎本 愛、池畑直樹、濵田勇人、古賀陽子、近津大地
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔扁平上皮癌におけるM2マクロファージ発現の臨床病理学的検討2015

    • Author(s)
      河野通秀、里見貴史、長谷川温、渡部正人、池畑直樹、榎本 愛、虻川東嗣、古賀陽子、近津大地
    • Organizer
      第60回日本口腔外科学会総会・学術大会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Book] イラストでみる口腔外科手術2015

    • Author(s)
      近津大地、野間弘康、栗田賢一、木村博人、瀬戸晥一、福田仁一、山根源之、朝波惣一郎
    • Total Pages
      336
    • Publisher
      クインテッセンス出版
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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