Elucidation of inhibitory mechanisms by salivary histatin in influenza viral infection and its induced inflammation
| Project/Area Number |
26462861
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
雪田 聡 静岡大学, 教育学部, 准教授 (80401214)
安藤 宏 松本歯科大学, 歯学部, 准教授 (30312094)
増田 裕次 松本歯科大学, 総合歯科医学研究所, 教授 (20190366)
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| Co-Investigator(Renkei-kenkyūsha) |
WANG Pao-Li 大阪歯科大学, 歯学部, 教授 (20213613)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 唾液蛋白質 / ヒスタチン |
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| Outline of Final Research Achievements |
Salivary protein histatins have antimicrobial properties and protect living organism from pathogens. Although there are antiviral actions in saliva, the detailed salivary components are not clarified. Because histatins are innate immune-related factors involved in biophylaxis, histatins are likely to have anti-influenza viral actions. In this study, histatin has turned out to be a salivary protein that inhibits the influenza viral constituent. It has also become apparent that histatin associates with another influenza viral constituent and a gram-positive bacterial one and inhibits them. These are the results of finding the new physiological function of salivary protein. These results are also connected with the future development of antiviral and anti-inflammatory agents.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Changes in Metallothionein Isoform Expression in the Bones of Ovariectomized Rats2016
Author(s)
Chiharu Sogawa, Mika Ikegame, Ikuko Miyazaki, Toshiaki Ara, Yasuhiro Imamura, Yuka Okusha, Kazumi Ohyama, Masato Asanuma, Norio Sogawa, Toshio Yamamoto, Ken-ichi Kozaki
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Journal Title
Journal of Hard Tissue Biology
Volume: 25
Issue: 1
Pages: 21-26
DOI
NAID
ISSN
1341-7649, 1880-828X
Related Report
Peer Reviewed / Open Access
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