| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Outline of Final Research Achievements |
All apoptotic cells express C5a receptor or produce and release its antagonist/agonist ligand ribosomal protein S19 (RP S19) polymer. When one of binding motives of RP S19 polymer binds to the C5a receptor on apoptotic cells in an autocrine manner, a lifespan of apoptotic cells is shorten through an activation of an apoptosis-inducing transcription factor delta-type lactoferrin. Next, another binding motives of RP S19 polymer bind to the C5a receptor on macrophages in an paracrine manner, a phagocytic time of apoptotic cells is shorten through an activation of a calcium channel-opening factor wild-type annexin A3.
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