| Project/Area Number |
26462864
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
楠川 仁悟 久留米大学, 医学部, 教授 (30258412)
讃井 彰一 九州大学, 大学病院, 講師 (70507780)
福田 隆男 九州大学, 歯学研究院, 助教 (80507781)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | シグナル伝達 / エナメル上皮腫 / 上皮成長因子 / AM-1 細胞 |
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| Outline of Final Research Achievements |
In the ameloblastoma cell line AM-1 cells, Sprouty 2 was found to be strongly induced upon EGF stimulation. On the other hand, when the influence of Sprouty 2 on its proliferation activity in resected sections of ameloblastoma was analyzed, the expression of Ki - 67 was suppressed in the site where Sprouty2 was strongly expressed. In addition, as an action of Sprouty 2 in the bone that is the origin of ameloblastoma, it inhibited proliferation by BMP 2 stimulation and suppressed cytokine secretion.
From the above results, it was found that EGF - induced Sprouty2 in enamel epithelioma suppresses tumor growth by controlling FGF stimulus suppressively.
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