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Development of materials for dentin hypersensitivity : Analysis of retrogression with transmission model

Research Project

Project/Area Number 26462870
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionTohoku University

Principal Investigator

Kanehira Masafumi  東北大学, 歯学研究科, 助教 (30177539)

Co-Investigator(Kenkyū-buntansha) 石幡 浩志  東北大学, 歯学研究科, 助教 (40261523)
高橋 英和  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90175430)
Co-Investigator(Renkei-kenkyūsha) ARAKI Yasuyuki  東北大学, 多元物質科学研究所, 准教授 (80361179)
Research Collaborator FINGER Werner, J.  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords象牙質透過性 / 知覚過敏 / マイクロフロー / 光化学 / 象牙知覚過敏 / 知覚過敏抑制材 / リン酸カルシウム / ハイドロキシアパタイト / マイクロフローセンサー
Outline of Final Research Achievements

The cause of regression of hypersensitivity has not been elucidated yet. We established a quantitative measurement system of dentin permeability to analyze the time-based effect for hypersensitivity.The process was analyzed through the morphological analysis and the measurement of dentin permeability after the improvement of equipment. As a result, new device made it possible to measure the hydraulic conductance and was clarified the differences in the permeability suppression mechanism of different materials. The particle size distribution, the significance of crystal formation, the amount of internal crystals and the changes of structure were also clarified. These findings were expected to become base evidence for developing safe and effective therapeutic agents of dentinal hyperesthesia.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Effect of two desensitizing agents on dentin permeability in vitro2017

    • Author(s)
      Hiroshi ISHIHATA, Masafumi KANEHIRA, Werner J. FINGER, Hidekazu TAKAHASHI, Makoto TOMITA, Keiichi SASAKI
    • Journal Title

      Journal of Applied Oral Science

      Volume: 25 Issue: 1 Pages: 34-41

    • DOI

      10.1590/1678-77572016-0228

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Effect of two dentin desensitizing agents on dentin disc permeability2016

    • Author(s)
      Masafumi KANEHIRA, Hiroshi ISHIHATA, Keiichi SASAKI, Masahiro SAITO
    • Organizer
      94th General Session & Exhibition of the IADR, 3rd Meeting of the IADR Asia Pacific Region, 35th Annual Meeting of the IADR Korean Division
    • Place of Presentation
      ソウル、大韓民国
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Can in vivo efficacy of dentin desensitizers be predicted by in vitro dentin permeability measurements?2016

    • Author(s)
      Kanehira M, Ishihata H, Mehta D, Finger WJ
    • Organizer
      Innovative Research for Biosis-Abiosis Intelligent Interface Symposium
    • Place of Presentation
      仙台
    • Year and Date
      2016-01-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Randomized, controlled clinical trial on dentin desensitization with a calcium phosphate containing paste2015

    • Author(s)
      KANEHIRA Masafumi, MEHTA Deepak, MOOGI Prashant, SURESH Venkata, RUPESH Maratham C., SAITO Masahiro, SASAKI Keiichi
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      北九州市
    • Year and Date
      2015-06-25 – 2015-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Randomized, controlled clinical trial on dentin desensitization with a calcium phosphate containing paste2015

    • Author(s)
      KANEHIRA Masafumi, MEHTA Deepak, MOOGI Prashant, SURESH Venkata, RUPESH Maratham C., SAITO Masahiro, SASAKI Keiichi
    • Organizer
      日本歯科保存学会2015年度春季学術大会
    • Place of Presentation
      北九州
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Book] Interface Oral Health Science 2014 Innovative Research on Biosis-Abiosis Intelligent Interface2015

    • Author(s)
      K. Sasaki, O. Suzuki, N. Takahashi, M. Kanehira, H. Ishihata, M. Saito, T. Hanawa, K. Ogasawara, H. Yatani, H. Egusa, H. Shimauchi, H. Takada, T.Yamamoto, T. Inoue, K. Matsuzaka, G Mayanagi, J Washio, J Matsuyama, N. Takahashi
    • Total Pages
      351
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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