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The development of a novel preventive method of periodontal disease using S-PRG Filler eluate

Research Project

Project/Area Number 26462871
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionTohoku University

Principal Investigator

Iwamatsu-Kobayashi Yoko  東北大学, 歯学研究科, 助教 (50261524)

Co-Investigator(Kenkyū-buntansha) 齋藤 正寛  東北大学, 歯学研究科, 教授 (40215562)
島内 英俊  東北大学, 歯学研究科, 名誉教授 (70187425)
Co-Investigator(Renkei-kenkyūsha) SUZUKI OSAMU  東北大学, 大学院歯学研究科, 教授 (60374948)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsPeriodontal disease / Bone loss / Inflammation / S-PRG filler / S-PRGフィラー / 歯周炎予防 / 金属イオン / 炎症性細胞浸潤 / 骨吸収
Outline of Final Research Achievements

S-PRG filler, a component of composite resin, is capable of releasing 6 metal ions that possess antibacterial activity against caries and periodontal pathogens. Although S-PRG has been suggested to be involved in oral disease prevention, no reports have been published regarding its preventive effect on periodontal disease in vivo. The present study investigated whether the eluate from S-PRG (S-PRG eluate) has a preventive effect on a mouse model of ligature-induced periodontal disease.
C57BL/6 mice were divided into three groups; no ligature, ligature and ligature with S-PRG eluate group. S-PRG eluate clearly inhibited alveolar bone loss of ligature-induced periodontal disease and reduced the infiltration of inflammatory cells. TOF-SIMS analysis revealed that more boron ions were present in the S-PRG group. Our results suggest that the S-PRG eluate has a preventive effect against tissue destruction in periodontal disease through its anti-inflammatory effects in vivo.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results)

  • [Journal Article] Metal ions from S-PRG filler have the potential to prevent periodontal disease2017

    • Author(s)
      Iwamatsu-Kobayashi Y, Abe S, Fujieda Y, Orimoto A, Kanehira M, Handa K, Venkataiah V S, Zou W, Ishikawa M, and Saito M
    • Journal Title

      Clinical and Experimental Dental Research

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 新規チタン製バリアメンブレンの各種培養細胞への効果2015

    • Author(s)
      遠藤直樹、小林洋子、石幡浩志、岩間張良、菊池雅彦
    • Journal Title

      日本歯科保存学雑誌

      Volume: 58(6) Pages: 503-509

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Pannexin 3 によるWnt/b-cateninおよびp21 signalingを介した骨前駆細胞の増殖機構の解析2016

    • Author(s)
      石河真幸、小林洋子、折本愛、半田慶介、齋藤正寛
    • Organizer
      第145回日本歯科保存学会秋季学術大会
    • Place of Presentation
      松本
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] The effect of S-PRG filler eluate on periodontitis models2016

    • Author(s)
      IWAMATSU-KOBAYASHI Yoko, ORIMOTO Ai, VENKATAIAH Venkata Suresh, KANEHIRA Masafumi, HANDA Keisuke and SAITO Masahiro
    • Organizer
      The 6th International symposium for interface oral health science
    • Place of Presentation
      Sendai
    • Year and Date
      2016-01-18
    • Related Report
      2015 Research-status Report
  • [Presentation] S-PRGフィラー抽出液由来イオンによるマウス歯周炎モデル抑制機構の解析2015

    • Author(s)
      小林洋子、兼平正史、半田慶介、齋藤正寛
    • Organizer
      第143回日本歯科保存学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] マルファン症候群モデルマウスにおける歯周炎の組織破壊機構に関する研究2015

    • Author(s)
      半田慶介、折本愛、小林洋子、齋藤正寛
    • Organizer
      第142回日本歯科保存学会春季学術大会
    • Place of Presentation
      北九州
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of S-PRG filler as a dental material that has an ability of perventing periodontal disease2015

    • Author(s)
      Iwamatsu-Kobayashi Yoko, Orimoto Ai, Handa Keisuke, Saito Masahiro
    • Organizer
      IADR
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2015-03-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of S-PRG filler eluate on the tissue destruction of the ligature-induced periodontitis model2014

    • Author(s)
      Iwamatsu-Kobayashi Yoko, Orimoto Ai, Handa Keisuke, Saito Masahiro
    • Organizer
      JADR
    • Place of Presentation
      Osaka
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] S-PRGフィラー抽出液によるマウス歯周炎モデル予防効果の解析2014

    • Author(s)
      小林洋子、安倍翔大、折本愛、齋藤正寛
    • Organizer
      第141回日本歯科保存学会秋季学術大会
    • Place of Presentation
      山形
    • Year and Date
      2014-10-30
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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