Paradigm shift of strategies for the control of oral biofilm and a novel antibiofilm chemotherapy targeting exopolysaccharide synthesis.
| Project/Area Number |
26462876
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大島 勇人 新潟大学, 医歯学系, 教授 (70251824)
寺尾 豊 新潟大学, 医歯学系, 教授 (50397717)
小田 真隆 京都薬科大学, 薬学部, 教授 (00412403)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | バイオフィルム / 化学的コントロール / 分散 / 剥離 / 共焦点レーザー顕微鏡 / 口腔ケア |
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| Outline of Final Research Achievements |
Chemical complements such as toothpaste and mouthrinses that contain antimicrobial agents have proven to be effective for the control of oral biofilm. However, we have demonstrated some adverse effects of antimicrobial agents. One adverse effect is that most of the antimicrobial agents failed to remove the biofilm structure. The residual structure may serve as a scaffold for the redevelopment of biofilm. Another effect is that low-dose antibiotics may promote bacterial biofilm formation. Taken together, future strategies that promote the biofilm matrix detachment are expected, without affecting bacterial growth targeting to polymeric substances.
We have developed a novel antibiofilm chemotherapy targeting exopolysaccharide synthesis. Vizantin, a recently developed immunostimulating compound, possessed antibiofilm activity against Streptococcus mutans without affecting bacterial growth. This compound causes S. mutans biofilm to detach by altering its internal architecture.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development.2015
Author(s)
Ohsumi, T., Takenaka, S., Wakamatsu, R., Sakaue, Y., Narisawa, N., Senpuku, H., Ohshima, H., Terao, Y., and Okiji, T.
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Journal Title
PLoS one
Volume: 10
Issue: 1
Pages: e0116647-e0116647
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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