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Multi-faceted analysis in acid resistance and remineralization of root dentin and establishment of clinical evaluation method

Research Project

Project/Area Number 26462879
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

IWAMI Yukiteru  大阪大学, 歯学研究科, 招へい教員 (90303982)

Co-Investigator(Kenkyū-buntansha) 林 美加子  大阪大学, 歯学研究科, 教授 (40271027)
山本 洋子  大阪大学, 歯学研究科, 招へい教員 (60448107)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsフッ素 / 定量測定法 / う蝕 / 加速器 / PIXE/PIGE / 脱灰 / カルシウム / う蝕評価
Outline of Final Research Achievements

The evaluation method of caries due to the change of calcium using In-air micro-PIXE / PIGE measurement method developed by us correlated with the decalcification evaluation by micro CT. Although the effect of dental caries control by fluorine contained in the tooth is obvious, it was found that fluorine can be further suppressed for caries by coexisting with calcium.
Clinical evaluation by laser diagnostic equipment, objective color diagnostic method, quantitative photoexcited fluorescence method, etc. has been great influenced of individual difference and environment, and further data accumulation was necessary to summarize relevance. We were able to take the first step in the development of new materials for root caries prevention.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 2015 2014

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Efficacy of a new filler-containing root coating material for dentin remineralization2016

    • Author(s)
      Okuyama K, Kadowaki Y, Matsuda Y, Hashimoto N, Oki S, Yamamoto H, Tamaki Y, Sano H
    • Journal Title

      American Journal of Dentistry

      Volume: 29 Pages: 213-218

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The demineralization inhibit effect of fluoride-containing sealants for primary teeth2016

    • Author(s)
      Matsuda Y, Ushimura S, Okuyama K, Komatsu H, Yamamoto H, Hashimoto N, Hayashi M, Nomachi M, Yasuda K, Satoh T, Koka M
    • Journal Title

      JAEA Takasaki Annual Report 2014 JAEA-Review 2015

      Volume: 22 Pages: 83-83

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluoride varnish remaining after physical stress2016

    • Author(s)
      Matsuda Y, Okuyama K, Komatsu H, Yamamoto H, Hashimoto N, Hayashi M, Nomachi M, Yasuda K, Satoh T, Koka M
    • Journal Title

      QST Takasaki Annual Report 2015

      Volume: なし Pages: 152-152

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大気マイクロPIXE/PIGEを用いた歯根面象牙質における脱灰のpHによる影響2016

    • Author(s)
      奥山克史、山本洋子、松田康裕、八木香子、安田啓介、鈴木耕拓、林美加子、玉置幸道、斎藤隆史、能町正治、菅谷頼仁
    • Journal Title

      若狭湾エネルギー研究センター研究年報(平成27年度)

      Volume: 18 Pages: 76-77

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The demineralization inhibit effect of fluoride-containing sealants for primary teeth2016

    • Author(s)
      Matsuda Y, Ushimura S, Okuyama K, Komatsu H, Yamamoto H, Hashimoto N, Hayashi M, Nomachi M, Yasuda K, Satoh T, Koka M
    • Journal Title

      JAEA Takasaki Annual Report 2014 JAEA-Review

      Volume: 2015-022 Pages: 83-83

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tooth-bound fluoride uptake from fluoride-containing dental materials2015

    • Author(s)
      Komatsu H, Okuyama K, Yamamoto H, Yasuda K, Nomachi M, Sugaya Y
    • Journal Title

      International Journal of PIXE

      Volume: 23 Issue: 03n04 Pages: 127-134

    • DOI

      10.1142/s0129083513410052

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluorine uptake into the human enamel surface from fluoride-containing sealing materials during cariogenic pH cycling2015

    • Author(s)
      Matsuda Yasuhiro, Okuyama Katsushi, Yamamoto Hiroko, Komatsu Hisanori, Koka Masashi, Sato Takahiro, Hashimoto Naoki, Oki Saiko, Kawamoto Chiharu, Sano Hidehiko
    • Journal Title

      Nuclear Instruments and Methods in Physics Research B

      Volume: 348 Pages: 156-159

    • DOI

      10.1016/j.nimb.2015.01.062

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new technique for analyzing trace element uptake by human enamel2015

    • Author(s)
      Funato Y, Matsuda Y, Okuyama K, Yamamoto H, Komatsu H, Sano H
    • Journal Title

      Dental Materials Journal

      Volume: 34 Issue: 2 Pages: 240-245

    • DOI

      10.4012/dmj.2014-127

    • NAID

      130005062410

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 歯根面象牙質における脱灰評価へのマイクロPIXE/PIGEの応用2015

    • Author(s)
      奥山克史、山本洋子、松田康裕、小松久憲、佐野英彦、安田啓介、鈴木耕拓、林美加子、能町正治、菅谷頼仁
    • Journal Title

      若狭湾エネルギー研究センター研究年報(平成26年度)

      Volume: 17 Pages: 31-32

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] フッ化物含有う蝕予防材による脱灰抑制効果のマイクロPIXE/PIGEによる評価2015

    • Author(s)
      松田康裕、奥山克史、山本洋子、小松久憲、江夏昌志、佐藤隆博、佐野英彦、安田啓介、鈴木耕拓、林美加子、能町正治、菅谷頼仁
    • Journal Title

      若狭湾エネルギー研究センター研究年報(平成26年度)

      Volume: 17 Pages: 33-34

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of caries progression in dentin treated by fluoride-containing materials using an in-air micro-PIGE and micro-PIXE measurement system2015

    • Author(s)
      H. Yamamoto, Y. Iwami, K. Yagi, M. Hayashi, H. Komatsu, K. Okuyama, Y. Matsuda, K.Yasuda
    • Journal Title

      Nuclear Instruments & Methods in Physics Research

      Volume: B348 Pages: 152-155

    • DOI

      10.1016/j.nimb.2015.01.068

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Distribution of fluoride penetrating from fluoride-containing filling materials in pre-demineralized enamel2015

    • Author(s)
      Matsuda Y, Okuyama K, Yamamoto H, Komatsu H, Oki S, Hashimoto N, Iwami Y, Hayashi M, Sano H, Nomachi M, Yasuda K, Satoh T, Koka M
    • Journal Title

      JAEA Takasaki Annual Report 2013 JAEA-Review 2014

      Volume: 050 Pages: 92-92

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 脱核反応による歯質中のフッ素分布測定132017

    • Author(s)
      松田康裕、斎藤隆史、奥山克史、山本洋子、岩見行晃、林美加子、能町正治、安田啓介、山田尚人、佐藤隆博
    • Organizer
      第1回QST高崎研シンポジウム
    • Place of Presentation
      高崎量子応用研究所(群馬県高崎市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Evaluation of the acid resistance of root dentin when applying fluoride containing materials incorporating Ca using in-air micro-PIXE/PIGE2016

    • Author(s)
      Yagi K, Yamamoto H, Uemura R, Okuyama K, Matsuda Y, Suzuki K, Hayashi M
    • Organizer
      International dental materials congress 2016
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] XRD and FT-IR analysis on fluoride-treated hydroxyapatite2016

    • Author(s)
      Okuyama K, Komada Y, Abe M, Matsuda Y, Yamamoto H, Tamaki Y
    • Organizer
      International dental materials congress 2016
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フッ化物含有知覚過敏抑制材による象牙質表面の脱灰抑制効果2016

    • Author(s)
      松田康裕、奥山克史、山本洋子、大木彩子、泉川昌宣、油井知雄、伊藤修一、佐野英彦、斎藤隆史
    • Organizer
      日本歯科保存学会2016年度秋季学術大会(第145回)
    • Place of Presentation
      長野県松本文化会館(長野県松本市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] Demineralize Prevention of Dentin With S-PRG Varnish via Automatic pH-cycling2016

    • Author(s)
      Matsuda Y, Okuyama K, Yamamoto H, Oki S, Izumikawa M, Yui T, Ito S, Sano H, Saito T
    • Organizer
      18th Joint scientific meeting of 146th scientific meeting of the Korean Academy of Conservative Dentistry (KACD) and JSCD
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of demineralization in root dentin using in-air micro PIXE/PIGE2016

    • Author(s)
      Yagi K, Uemura R, Yamamoto H, Matsuda Y, Okuyama K, Yasuda K, Hayashi M
    • Organizer
      94th General session of IADR
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In-air micro beam PIXE/PIGEによる根面象牙質の耐酸性評価-pHおよびフッ化物の影響に関する検討-2016

    • Author(s)
      八木香子、山本洋子、上村玲央、奥山克史、松田康裕、鈴木耕拓、林美加子
    • Organizer
      日本歯科保存学会2016年度春季学術大会(第144回)
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] フッ化物含有歯科材料によるフッ素のエナメル質への取り込みと結合状態の評価2015

    • Author(s)
      奥山克史、松田康裕、山本洋子、橋本直樹、林美加子、佐野英彦、玉置幸道
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      文京シビックホール〔東京都)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 核反応による歯質中のフッ素分布測定122015

    • Author(s)
      松田康裕、斎藤隆史、奥山克史、大木彩子、橋本直樹、佐野英彦、山本洋子、岩見行晃、林美加子、能町正治、安田啓介、山田尚人、喜多村茜、佐藤隆博
    • Organizer
      第10回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎量子応用研究所(高崎市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] In-air micro-beam PIXE/PIGEを用いた根面象牙質の脱灰評価2015

    • Author(s)
      八木香子、山本洋子、岩見行晃、林美加子
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 脱灰処理されたエナメル質におけるフッ化物含有材料からのフッ素の拡散2014

    • Author(s)
      松田康裕、奥山克史、小松久憲、大木彩子、橋本直樹、佐野英彦、山本洋子、岩見行晃、林美加子、能町正治、安田啓介、山田尚人、喜多村茜、佐藤隆博、江夏昌志
    • Organizer
      第9回高崎量子応用研究シンポジウム
    • Place of Presentation
      高崎
    • Year and Date
      2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Fluorine uptake into human enamel surface from fluoride-containing sealing materials during cariogenic pH cycling2014

    • Author(s)
      Y. Matsuda, K. Okuyama , M. Koka, T. Satoh, H. Komatsu and H.Sano
    • Organizer
      14th ICNMTA
    • Place of Presentation
      Padova, Italy
    • Year and Date
      2014-07-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Evaluation of caries progression in dentin treated by fluoride-containing materials using PIGE/PIXE system2014

    • Author(s)
      H. Yamamoto , Y. Iwami , K. Yagi, M. Hayashi , H. Komatsu , K. Okuyama , Y. Matsuda, and K. Yasuda
    • Organizer
      14th ICNMTA
    • Place of Presentation
      Padova, Italy
    • Year and Date
      2014-07-08
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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