Multi-faceted analysis of cause investigation on refractory periapical periodontitis
| Project/Area Number |
26462880
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野杁 由一郎 新潟大学, 医歯学総合研究科, 教授 (50218286)
伊藤 祥作 大阪大学, 歯学部附属病院, 講師 (90360495)
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| Co-Investigator(Renkei-kenkyūsha) |
ASAHI YOKO 大阪大学, 大学院歯学研究科, 助教 (50456943)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 歯内療法学 / 細菌 / バイオフィルム / 難治性根尖性歯周炎 / 16s rRNA遺伝子解析法 / CBCT / 咬合性外傷 |
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| Outline of Final Research Achievements |
To clarify the cause of refractory periapical periodontitis, bacterial biofilm on root apex obtained by apicoectomy or tooth extraction was investigated by PCR-based 16s rRNA gene assay. In addition, we performed morphologically examination by scanning electron microscope and clinical examination in oreder to analyze pathology from both the basic and clinical aspects. As a result, we demonstrated the various patterns of pathology on refractory periapical periodontitis conbined with multiple factors such as the 3D shape of apical lesion, anatomical form of root apex and occlusal trauma in addition to extraradicular biofilm.
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Report
(4 results)
Research Products
(2 results)
