Effects of aging on hard tissue formation using Low-intensity pulsed ultrasound and BMP
Project/Area Number |
26462883
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Conservative dentistry
|
Research Institution | Okayama University |
Principal Investigator |
YAMAJI KOZO 岡山大学, 大学病院, 講師 (30374531)
|
Co-Investigator(Kenkyū-buntansha) |
川浪 雅光 北海道大学, 歯学研究科, 名誉教授 (10133761)
吉山 昌宏 岡山大学, 医歯薬学総合研究科, 教授 (10201071)
菅谷 勉 北海道大学, 歯学研究科, 准教授 (10211301)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 低出力超音波パルス / BMP / 硬組織形成 / 加齢 |
Outline of Final Research Achievements |
This study evaluated the effects of aging on hard tissue formation induced by BMP using Low-intensity pulsed ultrasound(LIPUS)in young and aged rats. Tertialy dentin formation was promoted by using pulp capping material contained BMP when LIPUS treatment was performed. There was no significant difference between the young and the aged rat in the volume of tertialy dentin. Newly formed bone was promoted by implantation of material contained BMP at palatal subperiosteal site when LIPUS treatment was performed, although the volume of bone decreased with aging. These results suggest that the effects of aging on hard tissue formation might vary with the experimental sites.
|
Report
(4 results)
Research Products
(8 results)