A study of long-term durable and multi-functional fillers for dental adhesive

• Project/Area Number: 26462884
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Okayama University
• Principal Investigator: OGAWA TATSUYUKI 岡山大学, 医歯薬学総合研究科, 助手 (10346421)
• Co-Investigator(Kenkyū-buntansha): 吉原 久美子 岡山大学, 大学病院, 助教 (90631581)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯質接着材 / フィラー / シランカップリング / 透過電子顕微鏡 / 歯質接着材料 / ボンディング材 / コンポジットレジン / シランカップリング材 / ボンディング剤 / シランカップリング剤

Outline of Final Research Achievements

Composite resin has advantages of aesthetic, minimally invasive for teeth, so it is often used in daily practice. However, it has still problem in long term durability. One of the reason was due to degradation of silane coupling for fillers. However, there was no study to investigate the effect of filler types and its coupling method. So in this study, we investigated the influence of filler type and treatment method of filler on durability of fillers in adhesive layer by the electron microscope observation. It was found that type of fillers and its treatment affected the durability of the filler.

Research Products

• [Int'l Joint Research] KULeuven(ベルギー)
• [Int'l Joint Research] Federal University of Ceara at Fortaleza(ブラジル)
• [Journal Article] Chemical interaction of glycero-phosphate dimethacrylate (GPDM) with hydroxyapatite and dentin. (2018)
  • Author(s): Yoshihara K, Nagaoka N, Hayakawa S, Okihara T, Yoshida Y, Van Meerbeek B.
  • Journal Title: Dental Materials Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Etching Efficacy of Self-Etching Functional Monomers (2018)
  • Author(s): Yoshihara K.、Hayakawa S.、Nagaoka N.、Okihara T.、Yoshida Y.、Van Meerbeek B.
  • Journal Title: Journal of Dental Research Volume: 印刷中 Issue: 9 Pages: 1-7
  • DOI: 10.1177/0022034518763606
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Freshly-mixed and setting calcium-silicate cements stimulate human dental pulp cells (2018)
  • Author(s): Pedano M, Li X, Li S, Sun Z, Cokic S, Putzeys E, Yoshihara K, Yoshida Y, Chen Z, Van Landuyt K, Van Meerbeek B
  • Journal Title: Dental Materials Volume: 印刷中 Issue: 5 Pages: 1-12
  • DOI: 10.1016/j.dental.2018.02.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Crystallographic and morphological analysis of sandblasted highly translucent dental zirconia (2018)
  • Author(s): Inokoshi Masanao、Shimizu Haruki、Nozaki Kosuke、Takagaki Tomohiro、Yoshihara Kumiko、Nagaoka Noriyuki、Zhang Fei、Vleugels Jozef、Van Meerbeek Bart、Minakuchi Shunsuke
  • Journal Title: Dental Materials Volume: 34 Issue: 3 Pages: 508-518
  • DOI: 10.1016/j.dental.2017.12.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Light irradiance through novel CAD-CAM block materials and degree of conversion of composite cement (2018)
  • Author(s): Lise Diogo Pedrollo、Van Ende Annelies、De Munck Jan、Yoshihara Kumiko、Nagaoka Noriyuki、Cardoso Vieira Luiz Clovis、Van Meerbeek Bart
  • Journal Title: Dental Materials Volume: 34 Issue: 2 Pages: 296-305
  • DOI: 10.1016/j.dental.2017.11.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Micro-Raman Vibrational Identification of 10-MDP Bond to Zirconia and Shear Bond Strength Analysis (2017)
  • Author(s): De-Paula Diego Martins、Loguercio Alessandro D.、Reis Alessandra、Frota Natasha Marques、Melo Radames、Yoshihara Kumiko、Feitosa Victor Pinheiro
  • Journal Title: BioMed Research International. Volume: 2017 Pages: 1-7
  • DOI: 10.1155/2017/8756396
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Titanium implant functionalization with phosphate-containing polymers may favour in vivo osseointegration (2017)
  • Author(s): Cardoso MV, de Rycker J, Chaudhari A, Coutinho E, Yoshida Y, Van Meerbeek B, Mesquita MF, da Silva WJ, Yoshihara K, Vandamme K, Duyck J
  • Journal Title: J Clin Periodontology Volume: 44 Issue: 9 Pages: 950-960
  • DOI: 10.1111/jcpe.12736
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bacterial adhesion not inhibited by ion-releasing bioactive glass filler (2017)
  • Author(s): Yoshihara Kumiko、Nagaoka Noriyuki、Maruo Yukinori、Sano Hidehiko、Yoshida Yasuhiro、Van Meerbeek Bart
  • Journal Title: Dental Materials Volume: 33 Issue: 6 Pages: 723-734
  • DOI: 10.1016/j.dental.2017.04.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Chemical interaction mechanism of 10-MDP with zirconia (2017)
  • Author(s): Noriyuki Nagaoka, Kumiko Yoshihara, Victor Pinheiro Feitosa, Yoshiyuki Tamada, Masao Irie, Yasuhiro Yoshida, Bart Van Meerbeek, Satoshi Hayakawa
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 45563-45563
  • DOI: 10.1038/srep45563
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model. (2017)
  • Author(s): Cardoso MV, Chaudhari A, Yoshihara K, Mesquita MF, Yoshida Y, Van Meerbeek B, Vandamme K, Duyck J.
  • Journal Title: Int J Oral Maxillofac Implants. Volume: 32 Issue: 2 Pages: 282-290
  • DOI: 10.11607/jomi.5074
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sandblasting may damage the surface composite CAD-CAM blocks. (2017)
  • Author(s): Yoshihara K, Nagaoka N, Maruo Y, Nishigawa G, Irie M, Yoshida Y, Ban Meerbeek B.
  • Journal Title: Dental Materials Volume: 33 Issue: 3 Pages: 124-135
  • DOI: 10.1016/j.dental.2016.12.003
  • NAID: 120006401576
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Does 8-methacryloxyoctyl trimethoxy silane (8-MOTS) improve initial bond strength on lithium disilicate glass ceramic? (2017)
  • Author(s): Maruo Y, Nishigawa G, Yoshihara K, Minagi S, Matsumoto T, Irie M.
  • Journal Title: Dental Materials Volume: 33 Issue: 3 Pages: 95-100
  • DOI: 10.1016/j.dental.2016.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Modified tricalcium silicate cement formulations with added zirconium oxide. (2017)
  • Author(s): Li X, Yoshihara K, De Munck J, Cokic S, Pongprueksa P, Putzeys E, Pedano M, Chen Z, Van Landuyt K, Van Meerbeek B.
  • Journal Title: Clinical Oral Investigations Volume: 21 Issue: 3 Pages: 895-895
  • DOI: 10.1007/s00784-016-1843-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Does acid etching morphologically and chemically affect lithium disilicate glass ceramic surfaces? (2017)
  • Author(s): Maruo Y, Nishigawa G, Irie M, Yoshihara K, Matsumoto T, Minagi S.
  • Journal Title: Journal of Applied Biomaterials & Functional Materials Volume: 15 Issue: 1 Pages: 1218-1225
  • DOI: 10.5301/jabfm.5000303
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] No evidence for the growth-stimulating effect of monomers on cariogenic Streptococci. (2016)
  • Author(s): Nedeljkovic I, Yoshihara K, De Munck J, Teughels W, Van Meerbeek B, Van Landuyt KL.
  • Journal Title: Clinical Oral Investigations Volume: in Press Issue: 5 Pages: 1861-1869
  • DOI: 10.1007/s00784-016-1972-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Interference of functional monomers with polymerization efficiency of adhesives (2016)
  • Author(s): Hanabusa M, Yoshihara K, Yoshida Y, Okihara T, Yamamoto T, Momoi Y, Van Meerbeek B
  • Journal Title: European Journal of Oral Sciences Volume: 124 Issue: 2 Pages: 204-209
  • DOI: 10.1111/eos.12245
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Structural and Chemical Analysis of the Zirconia-Veneering Ceramic Interface. (2016)
  • Author(s): Inokoshi M, Yoshihara K, Nagaoka N, Nakanishi M, De Munck J, Minakuchi S, Vanmeensel K, Zhang F, Yoshida Y, Vleugels J, Naert I, Van Meerbeek B.
  • Journal Title: Journal of Dental Research Volume: 95 Issue: 1 Pages: 102-109
  • DOI: 10.1177/0022034515608825
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Various Effects of Sandblasting of Dental Restorative Materials. (2016)
  • Author(s): Nishigawa G, Maruo Y, Irie M, Maeda N, Yoshihara K, Nagaoka N, Matsumoto T, Minagi S.
  • Journal Title: PLoS One Volume: 11 Issue: 1 Pages: e0147077-e0147077
  • DOI: 10.1371/journal.pone.0147077
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Functional monomer impurity affects adhesive performance (2015)
  • Author(s): Yoshihara K, Nagaoka N, Okihara T, Kuroboshi M, Hayakawa S, Maruo Y, Nishigawa G, De Munck J, Yoshida Y, Van Meerbeek B
  • Journal Title: Dental Materials Volume: 31 Issue: 12 Pages: 1493-1501
  • DOI: 10.1016/j.dental.2015.09.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bone engineering by phosphorylated-pullulan and β-TCP composite. (2015)
  • Author(s): Takahata T, Okihara T, Yoshida Y, Yoshihara K, Shiozaki Y, Yoshida A, Yamane K, Watanabe N, Yoshimura M, Nakamura M, Irie M, Van Meerbeek B, Tanaka M, Ozaki T, Matsukawa A.
  • Journal Title: Biomed Mater. Volume: 10 Issue: 6 Pages: 065009-065009
  • DOI: 10.1088/1748-6041/10/6/065009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Flexural properties of polyethylene, glass and carbon fiber-reinforced resin composites for prosthetic frameworks. (2015)
  • Author(s): Maruo Y, Nishigawa G, Irie M, Yoshihara K, Minagi S.
  • Journal Title: Acta Odontol Scand Volume: 73 Issue: 8 Pages: 581-587
  • DOI: 10.3109/00016357.2014.958875
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] リン酸系モノマーのアパタイト・象牙質への化学的相互作用 (2015)
  • Author(s): 吉原久美子、長岡紀幸、井上哲、吉田靖弘
  • Journal Title: 接着歯学 Volume: 33 Pages: 196-203
  • Peer Reviewed
• [Journal Article] Impact of hydrophilicity and length of spacer chains on the bonding of functional monomers. (2014)
  • Author(s): Feitosa VP, Sauro S, Ogliari FA, Ogliari AO, Yoshihara K, Zanchi CH, Correr-Sobrinho L, Sinhoreti MA, Correr AB, Watson TF, Van Meerbeek B.
  • Journal Title: Dental Materials Volume: 30 Issue: 12 Pages: 317-323
  • DOI: 10.1016/j.dental.2014.06.006
  • Peer Reviewed
• [Presentation] EDS-(S)TEM observation and analysis of dentin caries re-mineralization (2017)
  • Author(s): Yoshihara K, Nagaoka N, Hara T, Nakamura A, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/AADR/CADR General Session & Exhibition
  • Place of Presentation: San Francisco, Calif., USA
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] Chemical interaction of a novel functional monomer with hydroxyapatite/dentin (2017)
  • Author(s): Yoshihara K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/AADR/CADR General Session & Exhibition
  • Place of Presentation: San Francisco, Calif., USA
  • Year and Date: 2017-03-22
  • Int'l Joint Research
• [Presentation] The effect of phosphoric-acid cleaning on chemical interaction of 10-MDP with zirconia. (2017)
  • Author(s): Yoshihara K, Nagaoka N, Yoshida Y, Van Meerbeek B, Hayakawa S..
  • Organizer: The annual meeting of Asia Bioceramic Society
  • Int'l Joint Research
• [Presentation] レジンセメントの曲げ強さに対する長期水中保管の影響 (2017)
  • Author(s): 吉原久美子, 長岡紀幸, 入江正郎，吉田靖弘
  • Organizer: 第36回日本接着歯学会学術大会
• [Presentation] The annual meeting of Asia Bioceramic Society (2017)
  • Author(s): Yoshihara K
  • Organizer: Brazil-Japan Joint research workshop on adhesive dentistry
  • Int'l Joint Research
• [Presentation] アルカリ環境が修復材料の耐久性に与える影響 (2017)
  • Author(s): 吉原 久美子, 長岡 紀幸, 小河 達之,吉田 靖弘
  • Organizer: 147回日本歯科保存学会春季学術大会
• [Presentation] Development of Self-Adhesive Pulp-Capping Agents Containing a Novel Acrylamide Monomer (2017)
  • Author(s): Yoshihara K, Nagaoka N, Yoshida Y, Van Meerbeek B.
  • Organizer: CED-IADR
  • Int'l Joint Research
• [Presentation] Rechargeable anti-bacterial efficacy of montmorillonite modified with cetylpyridinium chloride for dental materials (2017)
  • Author(s): YOSHIHARA K, Abe S, Nagaoka N, Makita Y, Obika H, Van Meerveek B, Yoshida Y.
  • Organizer: ADVANCES IN FUNCTIONAL MATERIALS
  • Int'l Joint Research
• [Presentation] 異なる種類のフィラーが1液型ボンディング材の粘性、耐久性に与える影響 (2017)
  • Author(s): 吉原久美子, 小河達之, 長岡紀幸, 吉田靖弘
  • Organizer: 146回日本歯科保存学会春季学術大会
• [Presentation] 10-MDP プライマー処理前の洗浄がジルコニアの接着に及ぼす影響 (2017)
  • Author(s): 吉原久美子, 長岡紀幸,丸尾幸憲, 吉田靖弘
  • Organizer: 日本補綴歯科学会第126回学術大会
• [Presentation] アクリルアミド系モノマー含有レジン添加型覆髄材の検討 (2017)
  • Author(s): 吉原久美子, 長岡紀幸,吉田靖弘
  • Organizer: 第69回 歯科理工学会 春期学術講演会
• [Presentation] 2ステップセルフエッチングボンディング材の長期臨床症例の接着界面観察 (2016)
  • Author(s): 吉原久美子，長岡紀幸，吉田靖弘
  • Organizer: 第35回接着歯学会学術大会
  • Place of Presentation: 北海道大学 学術交流会館
  • Year and Date: 2016-12-03
• [Presentation] リン酸エッチングの有無がユニバーサルアドヒーシブの象牙質接着耐久性に与える影響 (2016)
  • Author(s): 吉原久美子，長岡紀幸，吉田靖弘
  • Organizer: 第145回日本歯科保存学会 平成28年度秋季大会
  • Place of Presentation: キッセイ文化ホール （長野県松本文化会館）
  • Year and Date: 2016-10-27
• [Presentation] バイオアクティブガラス含有歯質接着剤の電子顕微鏡観察 (2016)
  • Author(s): 長岡紀幸，吉原久美子，吉田靖弘
  • Organizer: 第145回日本歯科保存学会 平成28年度秋季大会
  • Place of Presentation: キッセイ文化ホール （長野県松本文化会館）
  • Year and Date: 2016-10-27
• [Presentation] インプラント/骨界面の３次元観察 (2016)
  • Author(s): 長岡紀幸，吉原久美子，丸尾幸憲
  • Organizer: 第58回歯科基礎医学会学術大会サテライトシンポジウム
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2016-08-24
• [Presentation] リチウムシリケートセラミックの構造観察と分析 (2016)
  • Author(s): 吉原久美子，長岡紀幸，丸尾幸憲，西川悟郎，吉田靖弘
  • Organizer: 日本補綴歯科学会第125回学術大会
  • Place of Presentation: 石川県立音楽堂，ANAクラウンプラザホテル金沢
  • Year and Date: 2016-07-08
• [Presentation] Etching efficacy of self-etching functional monomers (2016)
  • Author(s): Yoshihara K, Watanabe S, Nagaoka N, Okihara T, Hayakawa S, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/APR General Session & Exhibition
  • Place of Presentation: Seoul, Republic of Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] Competitive interaction of 10-MDP and 4-MET with hydroxyapatite (2016)
  • Author(s): Yoshihara K, Hayakawa S, Nagaoka N, Yoshida Y, Van Meerbeek B
  • Organizer: IADR/APR General Session & Exhibition
  • Place of Presentation: Seoul, Republic of Korea
  • Year and Date: 2016-06-22
  • Int'l Joint Research
• [Presentation] Bioactive glass フィラー含有コンポジットレジンの表面性状の検討 (2016)
  • Author(s): 吉原久美子，長岡紀幸，佐野英彦，吉田靖弘
  • Organizer: 第144回日本歯科保存学会 平成28年度春季大会
  • Place of Presentation: 栃木県総合文化センター
  • Year and Date: 2016-06-09
• [Presentation] アクリルアミド系モノマー含有レジン系接着性シーラーの検討 (2016)
  • Author(s): 吉原久美子，長岡紀幸，吉田靖弘
  • Organizer: 第76回歯科理工学会春季学術講演会
  • Place of Presentation: 九州大学医学部百年講堂
  • Year and Date: 2016-04-16
• [Presentation] 新規リン酸モノマー含有ボンディング材の歯質接着性の評価 (2015)
  • Author(s): 吉原久美子、長岡紀幸、吉田靖弘
  • Organizer: 第34回日本接着歯学会学術大会
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2015-12-19
• [Presentation] 10-MDP含有レジンセメントの象牙質接着界面の解析 (2015)
  • Author(s): 吉原久美子、長岡紀幸、吉田靖弘
  • Organizer: 第143回日本歯科保存学会
  • Place of Presentation: 文京シビックホール
  • Year and Date: 2015-11-12
• [Presentation] 新規動揺歯固定および矯正用ブラケット接着材の曲げ特性 (2015)
  • Author(s): 入江正郎，田仲 持郎, 松本 卓也, 武田 宏明, 鳥井 康弘, 吉原 久美子
  • Organizer: 第143回日本歯科保存学会
  • Place of Presentation: 文京シビックホール
  • Year and Date: 2015-11-12
• [Presentation] Micro-morphological Changes Of Various CAD-CAM Blocks After Different Surface Treatments (2015)
  • Author(s): Emilija Bajraktarova Valjakova, Jan De Munck, Kumiko Yoshihara, Cvetanka Misevska, Anita Grozdanov, Marleen Peumans, Bart Van Meerbeek
  • Organizer: 47th CED-IADR Meeting
  • Place of Presentation: Belek-Antalya, Turkey
  • Year and Date: 2015-10-15
  • Int'l Joint Research
• [Presentation] tability of silane coupling agent in one bottle adhesive (2015)
  • Author(s): K. Yoshihara, N. Nagaoka, M. Irie, A. Sonoda, Y. Makita, Y. Yoshida, B. Van Meerbeek.
  • Organizer: Academy of Dental Materials
  • Place of Presentation: Maui, Hawaii, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] 長期持続可能な銀系抗菌剤の開発 (2015)
  • Author(s): 吉原久美子、長岡紀幸、吉田靖弘
  • Organizer: 第66回歯科理工学会秋期学術講演会
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2015-10-03
• [Presentation] 充填用グラスアイオノマーセメント I級窩洞適合性と歯質接着強さ (2015)
  • Author(s): 入江正郎，田仲 持郎, 松本 卓也, 武田 宏明, 鳥井 康弘, 吉山 昌宏, 吉原 久美子
  • Organizer: 第66回歯科理工学会秋期学術講演会
  • Place of Presentation: タワーホール船堀
  • Year and Date: 2015-10-03
• [Presentation] CAD/CAMレジンブロックに対するサンドブラスト処理の影響 (2015)
  • Author(s): 長岡 紀幸, 入江 正郎, 松本 卓也, 吉田 靖弘
  • Organizer: 第142回日本歯科保存学会
  • Place of Presentation: 北九州国際会議場および 西日本総合展示場
  • Year and Date: 2015-06-25
• [Presentation] 一液性処理材の歯質接着強さ 処理時間の影響 (2015)
  • Author(s): 入江正郎、田仲 持郎, 松本 卓也, 武田 宏明, 鳥井 康弘, 吉山 昌宏, 吉原 久美子
  • Organizer: 第142回日本歯科保存学会
  • Place of Presentation: 北九州国際会議場および 西日本総合展示場
  • Year and Date: 2015-06-25
• [Presentation] １液性ボンディング材中に含まれるシランカップリング材の カップリング効果の検討 (2015)
  • Author(s): 吉原久美子，長岡紀幸，入江正郎，西川悟郎，丸尾幸憲,皆木省吾, 吉田靖弘
  • Organizer: 第124回日本補綴歯科学会
  • Place of Presentation: 大宮ソニックシティ
  • Year and Date: 2015-05-30
• [Presentation] 機能性モノマー glycero-phosphate dimethacrylate (GPDM)とハイドロキシアパタイトとの化学的相互作用 (2015)
  • Author(s): 吉原久美子、長岡紀幸、吉田靖弘
  • Organizer: 第65回歯科理工学会春期学術講演会
  • Place of Presentation: 仙台市情報・産業プラザ
  • Year and Date: 2015-04-11
• [Presentation] In vitro long-term durability of composite resin (2015)
  • Author(s): Kumiko YOSHIHARA, Noriyuki NAGAOKA, Yukinori MARUO, Goro NISHIGAWA, Yasuhiro YOSHIDA, Bart VAN MEERBEEK
  • Organizer: The 6th International Congress Adhesive Dentistry
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-01-31
• [Funded Workshop] CED-IADR (2017)