Application of electromagnetic wave irradiation to deep caries lesion.
| Project/Area Number |
26462885
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
MATSUO Takashi 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (30173800)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
中西 正 徳島大学, 大学院医歯薬学研究部(歯学系), 准教授 (00217770)
湯本 浩通 徳島大学, 病院, 講師 (60284303)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 深在性齲蝕 / 歯髄炎 / 高周波/電磁波 / 歯髄細胞 / 象牙芽細胞 / 自然免疫機構 / 高周波/電磁波治療 / 電磁波・高周波 / 遺伝子発現 / Streptococcus mutans / 殺菌効果 / 骨芽細胞 / 成長因子 |
|---|
| Outline of Final Research Achievements |
Electromagnetic wave irradiation (EMWI) has inactivation or bactericidal activities. We intended to apply EMWI to deep caries lesion. In the deep lesions, bacteria invaded dentin along the dentinal tubules, but intact tissue exists around infected tubules. Hence, it needs to elucidate not only the effects to invading bacteria but also the pulpal cells. EMWI induce Joule heat that seems to harm pulpal cells. We clarified that this harmful effect occurred only small area around EMWI apparatus, and EMWI promoted the cell activities of hard tissue. These findings suggested that EMWI had beneficial effects to pulpal cells.
Odontoblasts in the pulp have projections in the dentinal tubules. Thereby, pulpitis occurs when its projections encounters the bacterial components. Hence, we studied the innate immunity of pulpal cells and elucidated that odontoblasts had pattern recognition receptors and when they bound to the bacterial components, they produced chemokines that evoked inflammation.
|
Report
(4 results)
Research Products
(17 results)
-
-
-
-
-
-
-
-
[Presentation] 新規開発したラット根管治療モデルを用いた電磁波根尖療法の評価2016
Author(s)
松井沙織, 呉本勝隆, 米田直道, 恵比須繁之, 湯本浩通, 的場一成, 石本卓也, 中野貴由, 野杁由一郎, 林美加子
Organizer
日本歯科保存学会2016年度秋季学術大会
Place of Presentation
キッセイ分化ホール, 長野県, 松本市
Year and Date
2016-10-27
Related Report
-
-
-
-
-
-
-
-
[Book] 第5版保存修復学212017
Author(s)
田上順次,奈良陽一郎,山本一世,斉藤隆史,阿南壽,北村知明,斎藤正寛,佐野英彦,新海航一,千田彰,西谷佳浩,野田守,林美加子,林善彦,平山聡司,福島正義,古澤成博,堀田正人,前田英史,松尾敬志 他60名
Total Pages
321
Publisher
永末書店
Related Report
-
[Book] 第2版保存修復学専門用語集2017
Author(s)
興地隆史,林美加子,阿南壽,石原裕一,新海航一,野田守,長谷川篤司,原宣興,古市保志,松島潔,吉山昌宏,赤峰昭文,池見宅司,恵比須繁之,片山直,加藤喜郎,北村知明,久保至誠,久保田稔,松尾敬志 他70名
Total Pages
129
Publisher
医歯薬出版
Related Report
