| Project/Area Number |
26462891
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
植原 治 北海道医療大学, 歯学部, 助教 (00709248)
斎藤 隆史 北海道医療大学, 歯学部, 教授 (40265070)
安彦 善裕 北海道医療大学, 歯学部, 教授 (90260819)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | エピジェネティクス / 歯髄保存療法剤 / 修復組織形成 / ヒストン脱アセチル化酵素阻害剤 / 再石灰化 |
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| Outline of Final Research Achievements |
Calcium hydroxide agents have been widely used as pulp conservative treatment. Some improvements are required for the better quality of the formed dentin and the shorter times to dentin formation. Histone deacetylase inhibitors (HDACi) involved in epigenetic modifications promoted osteoblastic differentiation and inhibited osteoclast differentiation. In this study, we examined whether HDACi promoted odontoblast differentiation in vitro. The results indicate that HDACis may promote differentiation of odontoblastic cells and induce their calcification. Some of HDACis may be useful agents for pulp conservative treatment.
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