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Effects of the analgesic drug for endodontic treatment on odontoblasts.

Research Project

Project/Area Number 26462894
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionTokyo Dental College

Principal Investigator

Shimada Miyuki  東京歯科大学, 歯学部, 非常勤講師 (60297348)

Co-Investigator(Kenkyū-buntansha) 渋川 義幸  東京歯科大学, 歯学部, 准教授 (30276969)
佐藤 正樹  東京歯科大学, 歯学部, 講師 (80598855)
木村 麻記  東京歯科大学, 歯学部, 助教 (90582346)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords歯内療法薬 / TRP channel / Odontoblast / Guaiacol / Trigeminal ganglion / TRP channel / 歯内治療薬 / TRP channels / Odontoblasts / trigeminal ganglion / 歯内治療学
Outline of Final Research Achievements

We investigated effects of the guaiacol on odontoblasts which play an important role in nociceptive process via activation of transient receptor potential (TRP) channels during stimulation applied to the dentin surface. Guaiacol evoked Ca2+ influx from the extracellular medium via TRP vanilloid subfamily members-3 channels on the plasma membrane of odontoblasts, while the drug did not inhibit hypotonic-stimulation-induced Ca2+ entry in odontoblasts. These results implied that analgesic effect on odontoblast by guaiacol is unlikely in the dentinal pain. The bradykinin-induced and a direct mechanical stimulation-induced intracellular Ca2+ concentration ([Ca2+]i) increases in trigeminal ganglion (TG) neurons were significantly inhibited by guaiacol. We suggested that guaiacol develops excellent analgesic effect on the pulpitis by inhibiting mechanosensitive ionic channels in TG neurons.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (56 results)

All 2018 2017 2016 2015 2014

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 9 results) Presentation (45 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] Potassium Currents Activated by Depolarization in Odontoblasts2017

    • Author(s)
      Kojima Yuki、Kimura Maki、Higashikawa Asuka、Kono Kyosuke、Ando Masayuki、Tazaki Masakzu、Shibukawa Yoshiyuki
    • Journal Title

      Frontiers in Physiology

      Volume: 8 Pages: 1078-1078

    • DOI

      10.3389/fphys.2017.01078

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ionotropic P2X ATP receptor channels mediate purinergic signaling in mouse odontoblasts.2017

    • Author(s)
      Shiozaki Y, Sato M, Kimura M, Sato T, Tazaki M, Shibukawa Y
    • Journal Title

      Frontiers in Physiology

      Volume: 8

    • DOI

      10.3389/fphys.2017.00003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High pH-Sensitive TRPA1 Activation in Odontoblasts Regulates Mineralization2016

    • Author(s)
      Kimura M, Sase T, Higashikawa A, Sato M, Sato T, Tazaki M, Shibukawa Y
    • Journal Title

      Journal of Dental Research

      Volume: 1 Issue: 9 Pages: 1-8

    • DOI

      10.1177/0022034516644702

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intercellular signal communication among odontoblasts and trigeminal ganglion neurons via glutamate2016

    • Author(s)
      Nishiyama A, Sato M, Kimura M, Katakura A, Tazaki M, Shibukawa Y
    • Journal Title

      Cell Calcium

      Volume: 60 Issue: 5 Pages: 341-355

    • DOI

      10.1016/j.ceca.2016.07.003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Expression and function of purinergic P2Y12 receptors in rat trigeminal ganglion neurons.2015

    • Author(s)
      Kawaguchi A, Sato M, Kimura M, Ichinohe T, Tazaki M, Shibukawa Y.
    • Journal Title

      Neuroscience Research

      Volume: 98 Pages: 17-27

    • DOI

      10.1016/j.neures.2015.04.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Depolarization-induced Intracellular Free Calcium Concentration Increases Show No Desensitizing Effect in Rat Odontoblasts2015

    • Author(s)
      Kojima Y, Higashikawa A, Kimura M, Sato M, Mochizuki H, Ogura K, Sase T, Shinya A, Kobune K, Furuya T, Sato T, Shibukawa Y, Tazaki M
    • Journal Title

      The Bulletin of Tokyo Dental College

      Volume: 56 Issue: 2 Pages: 131-134

    • DOI

      10.2209/tdcpublication.56.131

    • NAID

      130005078126

    • ISSN
      0040-8891
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons2015

    • Author(s)
      Kawaguchi A, Sato M, Kimura M, Yamazaki T, Yamamoto H, Tazaki M, Ichinohe T, Shibukawa Y
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 9 Pages: 229-229

    • DOI

      10.3389/fncel.2015.00229

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intercellular odontoblast communication via ATP mediated by pannexin-1 channel and phospholipase C-coupled receptor activation.2015

    • Author(s)
      Sato M, Furuya T, Kimura M, Kojima Y, Tazaki M, Sato T, Shibukawa Y.
    • Journal Title

      Frontiers in Physiology

      Volume: 6 Pages: 326-326

    • DOI

      10.3389/fphys.2015.00326

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transient Receptor Potential Cation Channel Subfamily Vanilloid Member 3 is not Involved in Plasma Membrane Stretch-induced Intracellular Calcium Signaling in Merkel Cells2015

    • Author(s)
      Higashikawa A, Kojima Y, Sato M, Kimura M, Ogura K, Mochizuki H, Sase T, Shinya A, Kobune K, Furuya T, Sato T, Shibukawa Y, Tazaki M.
    • Journal Title

      The Bulletin of Tokyo Dental College

      Volume: 56 Issue: 4 Pages: 259-262

    • DOI

      10.2209/tdcpublication.56.259

    • NAID

      130005129286

    • ISSN
      0040-8891
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Odontoblasts as sensory receptors: transient receptor potential channels, pannexin-1, and ionotropic ATP receptors mediate intercellular odontoblast-neuron signal transduction2015

    • Author(s)
      Shibukawa, Y., Sato, M., Kimura, M., Sobhan, U., Shimada, M., Nishiyama, A., Kawaguchi, A., Soya, M., Kuroda, H., Katakura, A., Ichinohe, T., and Tazaki, M.
    • Journal Title

      Pflügers Archiv European Journal of Physiology

      Volume: 467 Issue: 4 Pages: 843-863

    • DOI

      10.1007/s00424-014-1551-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Odontoblasts express plasma membrane Ca2+-ATPase 1 and 42018

    • Author(s)
      Kimura Maki, Higashikawa Asuka, Kojima Yuki, Terashima-Shigefuji Reiko, Inoue Hiroyuki, Nagai Sayoko, Kamata Satomi, Shimada Miyuki, Kuroda Hidetaka, Ogura Kazuhiro, Mochizuki Hiroyuki, Kouno Kyosuke, Ando Masayuki, Shibukawa Yoshiyuki, Tazaki Masakazu
    • Organizer
      第95回日本生理学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Alkali- and ADP-sensitive store-operated Ca2+ entry (SOCE) mediated by Ca2+ release-activated Ca2+ (CRAC) channels in rat odontoblasts.2017

    • Author(s)
      Kimura M., Sato M., Kojima Y., Higashikawa A., Shiozaki Y., Satou R., Shigefuji R., Shimada M., Kuroda H., Ogura K., Mochizuki H., Kouno K., Shibukawa Y., Tazaki M.
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松市
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 三叉神経節ニューロンに対するグアヤコールの鎮痛作用2017

    • Author(s)
      しま田みゆき,木村麻記,佐藤正樹,東川明日香,小島佑貴,田崎雅和,澁川義幸
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット三叉神経節グリア細胞の遅延整流型K+電流2017

    • Author(s)
      小島佑貴,東川明日香,大山定男,河野恭佑,安藤正之,西孝一,黒田英孝,木村麻記,澁川義幸,田﨑雅和
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] メルケル細胞-神経細胞間コミュニケーション2017

    • Author(s)
      東川明日香,小島佑貴,寺島‐重藤玲子,井上博之,河野恭佑,安藤正之,黒田英孝,木村麻記,澁川義幸,田﨑雅和
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 象牙芽細胞における高pH感受性store-operated Ca2+ entry(SOCE)2017

    • Author(s)
      木村麻記,小島佑貴,東川明日香,大山定男,しま田みゆき,安藤正之,河野恭祐,田崎雅和, 澁川義幸
    • Organizer
      第59回歯科基礎医学会学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 象牙質痛は象牙芽細胞と歯髄ニューロンの神経性伝達で生じる2017

    • Author(s)
      大山定男,木村麻記,人見涼露,田崎雅和,小野堅太郎,澁川義幸
    • Organizer
      第11回三叉神経領域の感覚-運動統合機構研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 象牙芽細胞に発現するTRPA1チャネルはアルカリ感受性を示し石灰化を促進する2016

    • Author(s)
      木村麻記,佐藤正樹,篠宏美,小野寺晶子,東川明日香,小島佑貴,塩崎雄大,佐藤涼一,重藤玲子,しま田みゆき,小倉一宏,望月浩幸,河野恭佑,澁川義幸,田崎雅和
    • Organizer
      第10回三叉神経領域の感覚-統合機能研究会
    • Place of Presentation
      佐久市
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 象牙芽細胞の低pH感受性カルシウム動員2016

    • Author(s)
      佐藤正樹,倉澤馨,岡林堅,木村麻記,小島佑貴,東川明日香,河野恭佑,澁川義幸,田崎雅和
    • Organizer
      第10回三叉神経領域の感覚-統合機能研究会
    • Place of Presentation
      佐久市
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 象牙芽細胞におけるアルカリ感受性store-operated Ca2+ entry(SOCE)2016

    • Author(s)
      木村麻記,佐藤正樹,小島佑貴,東川明日香,しま田みゆき,小倉一宏,望月浩幸,河野恭佑,田崎雅和,澁川義幸
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] Guaiacol は三叉神経節ニューロンに作用し鎮痛効果を発揮する2016

    • Author(s)
      しま田みゆき,木村麻記,佐藤正樹,東川明日香,小島佑貴,田崎雅和,澁川義幸
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] ラットTGニューロンにおける象牙芽細胞機械刺激誘発性活動電位記録2016

    • Author(s)
      佐藤正樹,木村麻記,小島佑貴,東川明日香,しま田みゆき,小倉一宏,望月浩幸,河野恭佑,澁川義幸,田崎雅和
    • Organizer
      第58回歯科基礎医学会学術大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-08-24
    • Related Report
      2016 Research-status Report
  • [Presentation] High pH-sensitive TRPA1 channel activation acts as a key Ca2+ signaling that regulates dentin mineralization by odontoblasts.2016

    • Author(s)
      Kimura M., Sato M., Kojima Y., Higashikawa A., Shimada M., Shiozaki Y., Satou R., Shigefuji R., Ogura K., Mochizuki H., Kouno K., Shibukawa Y., Tazaki M.
    • Organizer
      International Association of Dental Research (IADR) Pulp Biology and Regeneration Group (PBRG) Symposium 2016
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Store-operated Ca2+ entry in rat odontoblasts.2016

    • Author(s)
      Kimura M., Higashikawa A., Sato M., Kojima Y., Shimada M., Shiozaki Y., Satou R., Shigefuji R., Ogura K., Mochizuki H., Kouno K., Shibukawa Y., Tazaki M.
    • Organizer
      International Association of Dental Research (IADR) Pulp Biology and Regeneration Group (PBRG) Symposium 2016
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Odontoblasts as sensory receptors: Transient receptor potential channels, pannexin-1 and ionotropic ATP receptors, mediate intracellular odontoblast-trigeminal ganglion neuron signal transduction.2016

    • Author(s)
      Shibukawa Y., Sato M., Kimura M., Sobhan, U., Kojima Y., Higashikawa A., Shiozaki Y., Satou R., Shigefuji R., Shimada M., Ogura K., Mochizuki H., Kouno K., Tazaki M.
    • Organizer
      International Association of Dental Research (IADR) Pulp Biology and Regeneration Group (PBRG) Symposium 2016
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ATP released from odontoblasts by mechanosensitive TRP and piezo channel activations generates P2X3-mediated action potentials in trigeminal ganglion neurons.2016

    • Author(s)
      Sato M., Kimura M., Kojima Y., Higashikawa A., Shiozaki Y., Satou R., Shigefuji R., Shimada M, Ogura K., Mochizuki H., Kouno K., Tazaki M., Shibukawa Y.
    • Organizer
      International Association of Dental Research (IADR) Pulp Biology and Regeneration Group (PBRG) Symposium 2016
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Biophysical properties of a Voltage-dependent K+ current in odontoblasts.2016

    • Author(s)
      Kojima Y., Higashikawa A., Kimura M., Sato M., Shiozaki Y., Satou R., Shigefuji R., Shimada M., Ogura K., Mochizuki H., Kouno K., Shibukawa Y., Tazaki. M.
    • Organizer
      International Association of Dental Research (IADR) Pulp Biology and Regeneration Group (PBRG) Symposium 2016
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2016-06-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] High pH-sensitive TRPA1 channel activation in odontoblasts regulates dentin mineralization and calcification.2016

    • Author(s)
      Kimura M, Shibukawa Y, Sato M, Kojima Y, Higashikawa A, Kouno K, Shimada M, Mochizuki H, Ogura K, Tazaki M.
    • Organizer
      12th International Confference on Tooth Morphogenesis and Differentiation
    • Place of Presentation
      Finland
    • Year and Date
      2016-06-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A voltage-dependent K+ current showing activation and inactivation kinetics in rat odontoblasts.2016

    • Author(s)
      Kojima Y, Higashikawa A, Kimura M, Sato M, Mochizuki H, Ogura K, Shibukawa Y, Tazaki M.
    • Organizer
      12th International Confference on Tooth Morphogenesis and Differentiation
    • Place of Presentation
      Finland
    • Year and Date
      2016-06-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Expression of store-operated Ca2+ entry (SOCE) mediated by Ca2+ release-activated Ca2+ (CRAC) channels in rat odontoblasts2016

    • Author(s)
      Kimura M, Sato M, Kojima Y, Higashikawa A, Shiozaki Y, Satou R, Shigefuji R, Shimada M, Kobune K, Ogura K, Mochizuki H, Kouno K, Shibukawa Y, Tazaki M
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Evoked inward currents in trigeminal ganglion neurons caused by intracellular transmitters, ATP, released from mechanically stimulated odontoblasts2016

    • Author(s)
      Sato M, Kobune K, Kimura M, Kojima Y, Higashikawa A, Ogura K, Mochizuki H, Kouno K, Shimada M, Shibukawa Y, Tazaki M.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Merkel cells transduce mechanical stimulation into intercellular transmitter release2016

    • Author(s)
      Higashikawa A, Kojima Y, Kimura M, Sato M, Ogura K, Mochizuki H, Shibukawa Y, Tazaki M.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] A voltage-dependent K+ current in rat odontoblasts2016

    • Author(s)
      Kojima Y, Higashikawa A, Kimura M, Sato M, Mochizuki H, Ogura K, Shibukawa Y, Tazaki M.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Functional expression of P2X receptors in an odontoblast cell line.2016

    • Author(s)
      Shiozaki Y, Sato M, Kimura M, Shibukawa Y, Sato T, Tazaki M.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 象牙芽細胞における機械刺激感受性TRPV4チャネルとpiezo-1チャネルの機能的発現2016

    • Author(s)
      浅野一磨、佐藤正樹、木村麻記、河野恭佑、澁川義幸、田崎雅和
    • Organizer
      第302回東京歯科大学学会
    • Place of Presentation
      東京都
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児歯科臨床における歯内療法処置を考える2015

    • Author(s)
      坂井恵美、しま田みゆき、今泉千浪
    • Organizer
      日本小児歯科学会第34回中部地方会
    • Place of Presentation
      愛知県豊橋市
    • Year and Date
      2015-11-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Alkali stimulation-induced Ca2+ signaling in rat odontoblasts2015

    • Author(s)
      Shibukawa Y, Kimura M, Sato M, Kojima Y, Higashikawa A, Shimada M, Ogura K, Mochizuki H, Tazaki M
    • Organizer
      8th FAOPS congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 象牙芽細胞におけるアルカリ刺激受容機構の解明2015

    • Author(s)
      佐瀬俊之,木村麻記,佐藤正樹,東川明日香,小島佑貴,佐藤 亨,澁川義幸, 田﨑雅和
    • Organizer
      第300回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 三叉神経節ニューロンの象牙芽細胞機械刺激誘発性内向き電流の解析2015

    • Author(s)
      佐藤正樹,木村麻記,小島佑貴,東川明日香,西山明宏,塩崎雄大,佐藤涼一,重藤玲子,しま田みゆき,小倉一宏,望月浩幸,新谷明則,佐藤 亨,澁川義幸, 田﨑雅和
    • Organizer
      第300回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] メルケル細胞直接機械刺激による細胞内カルシウムシグナル2015

    • Author(s)
      東川明日香,小島佑貴,木村麻記,佐藤正樹,小倉一宏,望月浩幸,澁川義幸,田﨑雅和
    • Organizer
      第300回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 象牙芽細胞におけるイオンチャネル型ATP 受容体サブタイプ(P2X)の機能的検索2015

    • Author(s)
      塩崎雄大,佐藤正樹,木村麻記,澁川義幸,佐藤亨,田﨑雅和
    • Organizer
      第300回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット三叉神経節ニューロンにおけるB1受容体を介したCa2+動態の評価2015

    • Author(s)
      重藤玲子,川口綾,佐藤正樹,木村麻記,澁川義幸,田﨑雅和,一戸達也
    • Organizer
      第300回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット象牙芽細胞における電位依存性K+チャネルの生物物理学的特性解析2015

    • Author(s)
      小島佑貴,東川明日香,木村麻記,佐藤正樹,小倉一宏,望月浩幸,澁川義幸,田﨑雅和
    • Organizer
      第300回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 象牙芽細胞におけるstore-operated Ca2+ entry(SOCE)(Ca2+ release-activated Ca2+(CARC)channels)の発現2015

    • Author(s)
      木村麻記,佐藤正樹,小島佑貴,東川明日香,しま田みゆき,小倉一宏,望月浩幸,田崎雅和,澁川義幸
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 象牙芽細胞機械刺激で誘発される三叉神経節ニューロン内向き電流:象牙芽細胞-ニューロン共培養によるodontoblast hydrodynamic receptor theoryの電気生理学的解析2015

    • Author(s)
      佐藤正樹,木村麻記,小島佑貴,東川明日香,しま田みゆき,小倉一宏,望月浩幸,澁川義幸,田崎雅和
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟市
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Activated mechanisms of H+-sensing ionotropic receptors and G-protein-coupled H+-sensing receptors in odontoblasts2015

    • Author(s)
      Sato M, Kurasawa K, Okabayashi K, Kimura M, Kojima Y, Higashikawa A, Shimada M, Ogura K,Mochizuki H, Sase T, Shinya A, Kobune K, Shibukawa Y and Tazaki M
    • Organizer
      JOINT RESEARCH PROJECT (JSPS) UNDER THE JAPAN-KOREA BASIC SCIENTIFIC COOPERATION
    • Place of Presentation
      Narita, Chiba, Japan
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Alkaline-sensitive intracellular Ca2+ signaling pathway in rat odontoblasts2015

    • Author(s)
      Kimura M, Sato M, Kojima Y, Higashikawa A, Nishiyama A, Satou R, Shiozaki Y, Shimada M,Ogura K,Mochizuki H, Sase T, Shinya A, Kobune K, Furuya T, Sato T, Shibukawa Y, Tazaki M
    • Organizer
      JOINT RESEARCH PROJECT (JSPS) UNDER THE JAPAN-KOREA BASIC SCIENTIFIC COOPERATION
    • Place of Presentation
      Narita, Chiba, Japan
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ラット顎下腺由来唾液腺導管細胞株(SMIE)の時計遺伝子発現解析2015

    • Author(s)
      佐藤涼一,澁川義幸,石塚洋一,佐藤正樹,木村麻記,田﨑雅和,杉原直樹
    • Organizer
      第299回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] TRP チャネルを介した ATP 放出は象牙芽細胞間情報連絡を担う2015

    • Author(s)
      古屋 忠,佐藤正樹,木村麻記,小島佑貴,東川明日香,澁川義幸,田﨑雅和, 佐藤 亨
    • Organizer
      第299回東京歯科大学学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-06-06
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット顎下腺導管細胞の時計遺伝子Bmal1発現リズム解析2015

    • Author(s)
      佐藤涼一、石塚洋一、杉原直樹、澁川義幸、佐藤正樹、木村麻記、田﨑雅和
    • Organizer
      第65回日本口腔衛生学会・総会
    • Place of Presentation
      つくば市
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Guaiacol activates TRPV3 channels in mouse odontoblast-lineage cells2015

    • Author(s)
      Miyuki Shimada, Maki Kimura, Masaki Sato, Ubaidus Sobhan, Masakazu Tazaki, Yoshiyuki Shibukawa
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Ca2+ signaling activated by alkaline environment in rat odontoblasts2015

    • Author(s)
      Kimura Maki, Sato Masaki, Kojima Yuki, Higashikawa Asuka, Nishiyama Akihiro, Satou Ryoichi, Shiozaki Yuuta, Shimada Miyuki, Ogura Kazuhiro, Mochizuki Hiroyuki, Shibukawa Yoshiyuki, Tazaki Masakazu
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] グアヤコールの前投与は象牙芽細胞における低浸透圧刺激誘発性Ca2+流入を抑制する2014

    • Author(s)
      しま田みゆき,木村麻記,佐藤正樹,田崎雅和,澁川義幸
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 象牙芽細胞のアルカリ感受性象牙質形成機構の解明2014

    • Author(s)
      木村麻記,佐藤正樹,小島佑貴,東川明日香,しま田みゆき,小倉一宏,望月浩幸,田崎雅和,澁川義幸
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 象牙芽細胞における酸・機械刺激誘発性Ca2+流入はamilorideで抑制される2014

    • Author(s)
      倉澤馨,佐藤正樹,木村麻記,小島佑貴,東川明日香,小倉一宏,望月浩幸,しま田みゆき,澁川義幸,田崎雅和
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Book] 抜髄 Initial Treatment 治癒に導くための歯髄への臨床アプローチ2016

    • Author(s)
      澁川義幸、田崎雅和
    • Total Pages
      397
    • Publisher
      ヒョウロン・パブリッシャーズ
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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