| Project/Area Number |
26462912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
重光 竜二 東北大学, 大学病院, 助教 (00508921)
佐々木 啓一 東北大学, 歯学研究科, 教授 (30178644)
細川 亮一 東北大学, 歯学研究科, 臨床准教授 (40547254)
小関 健由 東北大学, 歯学研究科, 教授 (80291128)
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| Research Collaborator |
YAMAGUCHI KEIICHIRO 東北大学, サイクロトロンラジオアイソトープセンター, 研究教授
Li Qing The University of Sydney, Aerospace, Mechanical and Mechatronics Engineering, Professor
Swain Mike The University of Kuwait, Faculty of Dentistry, Professor
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | メカノバイオロジー / 骨代謝 / NaF-PET / FEA / 有限要素解析 / 顎堤吸収 / 有床義歯 / ＮａＦ－ＰＥＴ |
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| Outline of Final Research Achievements |
NaF Positron Emission Tomography (PET) can identify subtle functional variation prior to the major structural change detectable by X-ray. NaF-PET/CT scan was performed to examine the change of bone metabolism in the residual ridge underneath denture before and after the RPD treatment. The resultant mechanobiological response was analyzed using a 3D finite element (FE) model derived from the computerized tomography (CT) images of a corresponding patient under the occlusal loading. Mechanobiological stimulus determined from the FEA are quantified and compared with the standardized uptake values (SUV) of PET.
The increased application of occlusal force after RPD insertion induced higher mechanical stimuli in the residual bone, and SUV increased in the region of residual ridge with higher mechanical stimuli. SUV had clear correlation with mechanical stimulus in the cancellous bone, especially after RPD insertion (R2 > 0.8, p < 0.01).
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