• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Bone Augmentation Strategy with epigenetics small molecules

Research Project

Project/Area Number 26462915
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionNiigata University

Principal Investigator

AKIBA YOSUKE  新潟大学, 医歯学総合病院, 講師 (70547512)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsエピジェネティクス / 骨増生 / 多機能エピジェネティクス低分子化合物 / 多面的骨増生 / 多機能性エピジェネティクス低分子化合物 / ヒストン脱アセチル化酵素阻害剤 / ヒストン脱アセチル化阻害酵素 / 骨再生 / 細胞誘導
Outline of Final Research Achievements

The aim of this study was to evaluate epigenetics small molecule effect on acceleration of bone formation through regulation of inflammation, cell migration, and osteoblast differentiation. This study would help to establish bone augmentation therapy with multiple approach such as increasing of cell recruitment, vascularization, and mineralization. Valproic acid which had HDACi effect was used as epigenetic small molecule. VPA treatment with osteogenic differentiation stimulation showed significant increase in expressions of osteogenic marker gene compare to the osteogenic differentiation stimulation alone. VPA treatment also increased cell recruitment related gene and vascularization related gene expressions.
VPA treated cell transplantation to the calvarias cavity showed more bone formation than control cell transplantation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Biological Evaluation of Implant Drill Made from Zirconium Dioxide2017

    • Author(s)
      Y Akiba, K Eguchi, N Akiba, K Uoshima
    • Journal Title

      Clin Implant Dent Relat Res

      Volume: 19(2) Issue: 2 Pages: 306-315

    • DOI

      10.1111/cid.12452

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cell-based bone regeneration for alveolar ridge augmentation – Cell source, endogenous cell recruitment and immunomodulatory function2015

    • Author(s)
      Kaku M, Akiba Y, Akiyama K, Akita D, Nishimura M
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 59 Issue: 2 Pages: 96-112

    • DOI

      10.1016/j.jpor.2015.02.001

    • NAID

      130007936691

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] バルプロ酸(VPA)による新生骨形成促進作用の検討2014

    • Author(s)
      秋葉陽介
    • Organizer
      第3回あしなが予防医学研究会
    • Place of Presentation
      弘前 八戸グランドホテル
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 歯根膜には大腿骨骨髄に由来する幹細胞が存在する.2014

    • Author(s)
      加来 賢, 北見恩美, JM Rosales, 井田貴子, 秋葉陽介, 魚島勝美
    • Organizer
      第123回日本補綴歯科学会
    • Place of Presentation
      仙台 仙台国際会議場
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 多機能性エピジェネティクス化合物による骨増成法への多面的アプローチ.2014

    • Author(s)
      秋葉陽介,江口香織,秋葉奈美,北見恩美,Rocabado JMR,加来 賢,魚島勝美
    • Organizer
      第123回日本補綴歯科学会
    • Place of Presentation
      仙台 仙台国際会議場
    • Year and Date
      2014-05-24
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi