Bone Augmentation Strategy with epigenetics small molecules
| Project/Area Number |
26462915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Niigata University |
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Principal Investigator |
AKIBA YOSUKE 新潟大学, 医歯学総合病院, 講師 (70547512)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エピジェネティクス / 骨増生 / 多機能エピジェネティクス低分子化合物 / 多面的骨増生 / 多機能性エピジェネティクス低分子化合物 / ヒストン脱アセチル化酵素阻害剤 / ヒストン脱アセチル化阻害酵素 / 骨再生 / 細胞誘導 |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate epigenetics small molecule effect on acceleration of bone formation through regulation of inflammation, cell migration, and osteoblast differentiation. This study would help to establish bone augmentation therapy with multiple approach such as increasing of cell recruitment, vascularization, and mineralization. Valproic acid which had HDACi effect was used as epigenetic small molecule. VPA treatment with osteogenic differentiation stimulation showed significant increase in expressions of osteogenic marker gene compare to the osteogenic differentiation stimulation alone. VPA treatment also increased cell recruitment related gene and vascularization related gene expressions.
VPA treated cell transplantation to the calvarias cavity showed more bone formation than control cell transplantation.
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Report
(4 results)
Research Products
(5 results)
