Investigation The relationship between oral function and general health with Twin study

• Project/Area Number: 26462918
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Matsuda Kenichi 大阪大学, 歯学研究科, 助教 (80448109)
• Co-Investigator(Renkei-kenkyūsha): IKEBE KAZUNORI 大阪大学, 大学院歯学研究科, 准教授 (70273696)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 双子研究 / 口腔機能 / 動脈硬化 / 高齢双生児 / 双生児歯科検診 / データ整理

Outline of Final Research Achievements

This study was conducted to quantify the genetic and environmental contributions to oral disease and function in twins. Number of teeth,　percentage of decayed, filled and missing teeth and periodontal status were recorded. Furthermore, stimulated salivary flow rate,occlusal force and masticatory performance were　measured. Univariate genetic analysis with monozygotic and dizygotic　twin pairs was conducted to detect the fittest structural equation model of each outcome. Both　number of teeth and periodontal status fitted the model composed of common environmental factor　and unique environmental factor. Decayed, filled and missing teeth, morphological figures and　measurements of oral function fitted the model composed of additive genetic factor and unique　environmental factor. The model fitting of each measurement suggested that periodontal disease　was mainly affected by environmental factors, while oral functions　were influenced by both genetic and environmental factors.

Research Products

• [Journal Article] Influence of genetic and environmental factors on oral diseases and function in aged twins (2015)
  • Author(s): Y Kurushima, K Ikebe*, K Matsuda, K Enoki, S Ogata, M Yamashita, S Murakami, K Hayakawa, Y Maeda
  • Journal Title: J of Oral Rehabilitation Volume: 42 Issue: 1 Pages: 49-56
  • DOI: 10.1111/joor.12228
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Examination of the relationship between oral health and arterial sclerosis without genetic confounding through the study of older Japanese twins (2015)
  • Author(s): Yuko Kurushima, Kazunori Ikebe, Ken-ichi Matsuda, Kaori Enoki, Soshiro Ogata, Motozo Yamashita, Shinya Murakami, Yoshinobu Maeda, Osaka Twin Reseach Group
  • Journal Title: PLOS ONE Volume: 10 Issue: 5 Pages: e0127642-e0127642
  • DOI: 10.1371/journal.pone.0127642
  • Peer Reviewed
• [Journal Article] Influence of genetic and environmental factors on oral diseases and function in aged twins (2015)
  • Author(s): Kurushima Y, Ikebe K, Matsuda K, Enoki K, Ogata S, Yamashita M,
  • Journal Title: J Oral Rehabil Volume: in press
  • Peer Reviewed
• [Presentation] Relationship between Oral Health and Arterial Sclerosis Using Older Twins (2015)
  • Author(s): Kurushima Y, Ikebe K, Matsuda K, Enoki K, Ogata S
  • Organizer: 93th I.A.D.R. General Session
  • Place of Presentation: ボストン
  • Year and Date: 2015-03-11
• [Presentation] Do genetic factors have a role in the association between oral health and diabetes millitus? (2014)
  • Author(s): Kurushima Y,Ikebe K, Matsuda K, Enoki K, Ogata S, Osaka Twin Research Group
  • Organizer: GSA Annual Conference
  • Place of Presentation: ワシントンDC
  • Year and Date: 2014-11-06