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Fundamental research for clinical application of highly osteoconductive titanium implant to osteoporosis

Research Project

Project/Area Number 26462964
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Nozaki Kosuke  東京医科歯科大学, 生体材料工学研究所, 助教 (00507767)

Co-Investigator(Kenkyū-buntansha) 堀内 尚紘  東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
江部 典子  東京医科歯科大学, 生体材料工学研究所, 特任助教 (20611099)
Research Collaborator NAGAI Akiko  東京医科歯科大学, 生体材料工学研究所生体材料機能医学分野, 准教授 (40360599)
YAMASHITA Kimihiro  東京医科歯科大学, 生体材料工学研究所無機生体材料学分野, 教授 (70174670)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords歯科インプラント / 骨再生 / 表面粗さ / 骨芽細胞 / 表面改質 / チタンインプラント / 細胞増殖 / 細胞周期 / サンドブラスト / 陽極酸化 / 階層性構造 / チタンナノチューブ / 表面電荷 / 電気分極 / 骨粗鬆症
Outline of Final Research Achievements

Micro-/nanostructured implant surfaces mimicking natural bone architecture are expected to have positive effects on osteoblast proliferation. In this study, to clarify the optimal microstructure scale on micro-/nano-titanium surfaces, highly controlled microstructure surfaces were fabricated with a titania nanotube oxide layer by sandblast treatment and electrochemical anodization. Average surface roughness (Ra) and mean width of the profile elements (RSm) increased in proportion to the size of the blasting media. Osteoblast-like cells showed reduced spreading area on smaller microstructure surfaces after incubation for 24 h. Cell proliferation assays, including cell counting and cell cycle analyses, showed that micro-/nanosurfaces with smaller microstructures (Ra = 0.6 μm, RSm = 11.1 μm) had the most positive effect. This result indicated that smaller microstructures of hierarchical surfaces enhanced cell proliferation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (33 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (32 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Suppression effects of dental glass-ceramics with polarization-induced highly dense surface charges against bacterial adhesion2015

    • Author(s)
      Kosuke Nozaki, Hiroki Koizumi, Naohiro Horiuchi, Miho Nakamura, Toshinori Okura, Akiko Nagai and Kimihiro Yamashita
    • Journal Title

      Dental Materials Journal

      Volume: 34 Issue: 5 Pages: 671-678

    • DOI

      10.4012/dmj.2014-342

    • NAID

      130005101703

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Bone remodeling-optimization of carbonated apatite for guided bone regeneration2016

    • Author(s)
      Kosuke Nozaki, Kazuhisa Fujita, Hiroyuki Miura, Kimihiro Yamashita, Akiko Nagai
    • Organizer
      AADR/CADR Annual Meeting & Exhibition
    • Place of Presentation
      Los Angeles, CA, USA
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surface modification of Ti implant with controlled micro/nano-structured topography2016

    • Author(s)
      Natsuko Iwata, Kosuke Nozaki, Hiroyuki Miura, Kimihiro Yamashita, Akiko Nagai
    • Organizer
      AADR/CADR Annual Meeting & Exhibition
    • Place of Presentation
      Los Angeles, CA, USA
    • Year and Date
      2016-03-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] In vivo evaluation of the role of carbonate ion in hydroxyapatite for bone remodeling.2016

    • Author(s)
      Kosuke Nozaki, Kazuhisa Fujita, Naohiro Horiuchi, Miho Nakamura, Hiroyuki Miura, Kimihiro Yamashita, Akiko Nagai.
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Palais des congres de Montreal, Montreal, Canada
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Antibacterial activity of silver nanoparticles coating on zirconia against oral bacteria.2016

    • Author(s)
      Kosuke Nozaki, Risa Yamada, Hiroyuki Miura, Kimihiro Yamashita, Akiko Nagai.
    • Organizer
      The 1st International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development.
    • Place of Presentation
      Hotel Hankyu Expo Park, Suita, Osaka, Japan
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイクロ·ナノ階層構造チタニアによる骨芽細胞挙動の制御.2016

    • Author(s)
      岩田夏子, 野崎浩佑, 山下仁大, 三浦宏之, 永井亜希子.
    • Organizer
      第67回日本歯科理工学会学術大会
    • Place of Presentation
      九州大学医学部百年講堂,福岡市,福岡県
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗菌性イットリア部分安定型ジルコニア材料の種々の細菌に対する抗菌活性評価.2016

    • Author(s)
      山田理沙, 野崎浩佑,山下仁大,三浦宏之,永井亜希子.
    • Organizer
      第67回日本歯科理工学会学術大会
    • Place of Presentation
      九州大学医学部百年講堂,福岡市,福岡県
    • Related Report
      2016 Annual Research Report
  • [Presentation] 抗菌性を付与したイットリア部分安定型ジルコニア材料によるう蝕抑制評価.2016

    • Author(s)
      山田理沙,野崎浩佑,根本怜奈,山下仁大,三浦宏之,永井亜希子.
    • Organizer
      公益社団法人日本補綴歯科学会第 125 回学術大会
    • Place of Presentation
      石川県立音楽堂,ANAクラウンプラザホテル金沢,金沢市,石川県
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多様なマイクロ·ナノ構造を有するチタン材料による骨芽細胞挙動の制御.2016

    • Author(s)
      岩田夏子,野崎浩佑,山下仁大,三浦宏之,永井亜希子.
    • Organizer
      公益社団法人日本補綴歯科学会第 125 回学術大会
    • Place of Presentation
      石川県立音楽堂,ANAクラウンプラザホテル金沢,金沢市,石川県
    • Related Report
      2016 Annual Research Report
  • [Presentation] I型コラーゲン-ハイドロキシアパタイト複合体による歯根膜細胞挙動の制御.2016

    • Author(s)
      藤田和久,野崎浩佑,山下仁大,三浦宏之,永井亜希子.
    • Organizer
      公益社団法人日本補綴歯科学会第 125 回学術大会
    • Place of Presentation
      石川県立音楽堂,ANAクラウンプラザホテル金沢,金沢市,石川県
    • Related Report
      2016 Annual Research Report
  • [Presentation] 炭酸イオンにより骨形成と生体吸収速度を調和させたリン酸カルシウムの生体内評価.2016

    • Author(s)
      野崎浩佑,藤田和久,山下仁大,三浦宏之,永井亜希子.
    • Organizer
      公益社団法人日本補綴歯科学会第 125 回学術大会
    • Place of Presentation
      石川県立音楽堂,ANAクラウンプラザホテル金沢,金沢市,石川県
    • Related Report
      2016 Annual Research Report
  • [Presentation] 銀ナノ粒子コーティングを施したジルコニアに対する抗菌活性評価.2016

    • Author(s)
      山田理沙, 野崎浩佑, 三浦宏之, 山下仁大, 永井亜希子.
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場,福岡市,福岡県
    • Related Report
      2016 Annual Research Report
  • [Presentation] III型コラーゲンコートアパタイトによる歯根膜細胞の骨形成能制御.2016

    • Author(s)
      藤田和久,野崎浩佑,山下仁大,三浦宏之,永井亜希子.
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場,福岡市,福岡県
    • Related Report
      2016 Annual Research Report
  • [Presentation] アパタイト多孔体の骨形成能および吸収性を最適化するための炭酸含有量制御の試み.2016

    • Author(s)
      野崎浩佑,藤田和久,桑村雄太,三浦宏之,山下仁大,橋本和明,永井亜希子.
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場,福岡市,福岡県
    • Related Report
      2016 Annual Research Report
  • [Presentation] The effect of titania nanotube surfaces on osteoblast behavior2015

    • Author(s)
      Natsuko Iwata, Kosuke Nozaki, Hiroyuki Miura, Kimihiro Yamashita, Akiko Nagai
    • Organizer
      15th Asian Bioceramics Symposium
    • Place of Presentation
      Tokyo Medical and Dental University, Bunkyo-ku, Tokyo
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 骨形成と生体吸収性を調和させた炭酸含有アパタイト多孔体の作製とin vivo評価2015

    • Author(s)
      野崎浩佑, 藤田和久, 三浦宏之, 山下仁大, 永井亜希子
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ,京都市,京都
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
  • [Presentation] ナノチューブ表面構造形成によるチタニアの骨芽細胞挙動の制御2015

    • Author(s)
      岩田夏子, 野崎浩佑, 山下仁大, 三浦宏之, 永井亜希子
    • Organizer
      第37回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ,京都市,京都
    • Year and Date
      2015-11-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Bioresorbable and osteoconductive properties of porous carbonated apatite implanted in cortical and cancellous bone tissues2015

    • Author(s)
      Nozaki K, Fujita K, Ebe N, Miura H, Yamashita K, Nagai A
    • Organizer
      The 6th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-6)
    • Place of Presentation
      Waseda University, Shinjuku-ku, Tokyo
    • Year and Date
      2015-06-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 分極アパタイト上における細胞動態の解明2014

    • Author(s)
      桝谷峰旦, 野崎浩佑, 堀内尚紘, 中村美穂, 山下仁大, 永井亜希子
    • Organizer
      第18回生体関連セラミックス討論会
    • Place of Presentation
      大阪府立大学 I-siteなんば,大阪
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 塩素置換アパタイトを用いた分極バイオセラミックスの開発2014

    • Author(s)
      渡辺研太朗,堀内尚紘,野崎浩佑,中村美穂,永井亜希子,山下仁大
    • Organizer
      第18回生体関連セラミックス討論会
    • Place of Presentation
      大阪府立大学 I-siteなんば,大阪
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Investigation of cell dynamics on polarized HAp discs.2014

    • Author(s)
      Masutani T., Horiuchi N., Nozaki K., Nakamura M., Yamashita K., Nagai A.
    • Organizer
      The 5th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-5) Conjunction with 6th IBB Frontier Symposium.
    • Place of Presentation
      Tokyo Medical and Dental University, Tokyo
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of implanting position on bone formation in the porous carbonated apatite block.2014

    • Author(s)
      Nozaki K., Nagai A., Yamashita K.
    • Organizer
      The 5th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-5) Conjunction with 6th IBB Frontier Symposium.
    • Place of Presentation
      Tokyo Medical and Dental University, Tokyo
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Evaluation of surface charge on polarized hydroxyapatite using Kelvin probe method2014

    • Author(s)
      Horiuchi N, Ebe N, Nozaki K, Nakamura M, Nagai A, Yamashita K
    • Organizer
      The 5th International Symposium on Advanced Materials Development and Integration of Novel Structured Metallic and Inorganic Materials (AMDI-5) Conjunction with 6th IBB Frontier Symposium.
    • Place of Presentation
      Tokyo Medical and Dental University, Tokyo
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] ハイドロキシアパタイトを足場とした胚性幹細胞の培養2014

    • Author(s)
      永井亜希子,服部竜也,廣瀬美智子,小倉淳郎,野崎浩佑,相澤守,山下仁大
    • Organizer
      日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀,東京
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯科用イットリア安定化ジルコニア材料への抗菌活性付与の試み2014

    • Author(s)
      野崎浩佑,山田理沙,三浦宏之,山下仁大,永井亜希子
    • Organizer
      日本バイオマテリアル学会大会
    • Place of Presentation
      タワーホール船堀,東京
    • Year and Date
      2014-11-17 – 2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] The effects of carbonated hydroxyapatite on macrophage behaviors.2014

    • Author(s)
      Igeta K., Nagai A., Nozaki K., Aizawa M., Yamashita K.
    • Organizer
      26th Symposium and Annual Meeting of the International Society for Ceramics in Medicine.
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 誘電特性によるフッ素置換ハイドロキシアパタイトの構造評価2014

    • Author(s)
      堀内尚紘, 遠藤樹里亜,野崎浩佑, 中村美穂, 永井亜希子, 片山恵一, 山下仁大
    • Organizer
      第34回エレクトロセラミックス研究討論会
    • Place of Presentation
      東京工業大学,東京
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 抗菌性歯科用イットリア安定化ジルコニア材料の作製2014

    • Author(s)
      野崎浩佑,山田理沙,三浦宏之,山下仁大,永井亜希子
    • Organizer
      日本歯科理工学会学術講演会
    • Place of Presentation
      アステールプラザ ,広島
    • Year and Date
      2014-10-04 – 2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 破骨細胞の挙動へ与える分極アパタイトの効果2014

    • Author(s)
      難波咲, 中村美穂, 堀内尚紘, 野崎浩佑, 永井亜希子, 遠山岳史, 西宮伸幸, 山下仁大
    • Organizer
      セラミックス協会第27回秋季シンポジウム
    • Place of Presentation
      鹿児島大学,鹿児島
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 誘電特性に基づくフッ素置換ハイドロキシアパタイトの生体材料としての構造上の優位性に関する研究2014

    • Author(s)
      遠藤樹里亜,堀内尚紘,野崎浩佑,中村美穂,永井亜希子,片山恵一,山下仁大
    • Organizer
      セラミックス協会第27回秋季シンポジウム
    • Place of Presentation
      鹿児島大学,鹿児島
    • Year and Date
      2014-09-09 – 2014-09-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Fundamentals and Applications of Ceramic Electrets.2014

    • Author(s)
      Yamashita K, Horiuchi N, Nozaki K, Nagai A, Nakamura M
    • Organizer
      The 15th IUMRS-ICA 2014
    • Place of Presentation
      Fukuoka UniversityFukuoka
    • Year and Date
      2014-08-24 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 種々の埋入部位における炭酸置換型アパタイトの骨形成能変化の評価2014

    • Author(s)
      野崎浩佑,山下仁大,永井亜希子
    • Organizer
      日本補綴歯科学会第123回学術大会
    • Place of Presentation
      仙台国際センター,宮城
    • Year and Date
      2014-05-24 – 2014-05-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 種々の埋入部位におけるアパタイト骨形成能変化の評価2014

    • Author(s)
      野崎浩佑,山下仁大,永井亜希子
    • Organizer
      日本歯科理工学会学術講演会
    • Place of Presentation
      タワーホール船堀,東京
    • Year and Date
      2014-04-12 – 2014-04-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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