Qualitative analysis of the activated bone metabolism in bone regeneration with the cultured autogenous periosteal cell grafting by high quality 3D-CT image analysis
| Project/Area Number |
26462967
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
永田 昌毅 新潟大学, 医歯学系, 准教授 (10242439)
山田 一穂 新潟大学, 医歯学総合病院, 医員 (20397152)
川瀬 知之 新潟大学, 医歯学系, 准教授 (90191999)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 培養骨膜細胞 / 歯科インプラント / 骨再生 / 3D-CT / 画像解析 / 骨代謝 / 培養自家骨膜細胞 / ３D-CT |
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| Outline of Final Research Achievements |
Purpose: Evaluation of the effect of cultured autogenous periosteal cells (CAPC) on sinus lift (SL). Materials and Methods: SL with autologous bone and PRP plus CAPC [CAPC(+)SL] was performed in 23 cases. Pieces of mandibular periosteum were cultured in M199 medium with 10% FBS for 6 weeks. As control, 16 cases received SL with autologous bone and PRP [CAPC(-)SL]. High-resolution 3D-CT was performed before, 4 months and 1 year after SL, and stratified data based on CT numbers corresponding to soft tissue, cancellous bone, and cortical bone were subject to analysis. Results: CAPC(+)SL revealed an increase in CT numbers corresponding to cancellous bone as well as a decrease in those to cortical bone. CT numbers corresponding to cancellous bone were increased in CAPC(+)SL while they were decreased in CAPC(-)SL. Implant insertion torque was significantly higher in CAPC(+)SL. Conclusion: By promoting bone anabolic activity, CAPC is expected to aid osseointegration in clinical applications.
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Report
(4 results)
Research Products
(8 results)
