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Qualitative analysis of the activated bone metabolism in bone regeneration with the cultured autogenous periosteal cell grafting by high quality 3D-CT image analysis

Research Project

Project/Area Number 26462967
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionNiigata University

Principal Investigator

Hoshina Hideyuki  新潟大学, 医歯学総合病院, 講師 (30173587)

Co-Investigator(Kenkyū-buntansha) 永田 昌毅  新潟大学, 医歯学系, 准教授 (10242439)
山田 一穂  新潟大学, 医歯学総合病院, 医員 (20397152)
川瀬 知之  新潟大学, 医歯学系, 准教授 (90191999)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords培養骨膜細胞 / 歯科インプラント / 骨再生 / 3D-CT / 画像解析 / 骨代謝 / 培養自家骨膜細胞 / 3D-CT
Outline of Final Research Achievements

Purpose: Evaluation of the effect of cultured autogenous periosteal cells (CAPC) on sinus lift (SL). Materials and Methods: SL with autologous bone and PRP plus CAPC [CAPC(+)SL] was performed in 23 cases. Pieces of mandibular periosteum were cultured in M199 medium with 10% FBS for 6 weeks. As control, 16 cases received SL with autologous bone and PRP [CAPC(-)SL]. High-resolution 3D-CT was performed before, 4 months and 1 year after SL, and stratified data based on CT numbers corresponding to soft tissue, cancellous bone, and cortical bone were subject to analysis. Results: CAPC(+)SL revealed an increase in CT numbers corresponding to cancellous bone as well as a decrease in those to cortical bone. CT numbers corresponding to cancellous bone were increased in CAPC(+)SL while they were decreased in CAPC(-)SL. Implant insertion torque was significantly higher in CAPC(+)SL. Conclusion: By promoting bone anabolic activity, CAPC is expected to aid osseointegration in clinical applications.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 1 results)

  • [Journal Article] Non-invasive, quantitative assessment of the morphology of γ-irradiated human mesenchymal stem cells and periosteal cells using digital holographic microscopy2016

    • Author(s)
      Kawase T, Okuda K, Nagata M, Tsuchimochi M, Yoshie H, Nakata K.
    • Journal Title

      Int J Radiat Biol.

      Volume: 92(12) Issue: 12 Pages: 796-805

    • DOI

      10.1080/09553002.2016.1230242

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the safety of somatic periosteal cells by flow-cytometric analysis monitoring the history of DNA damage2016

    • Author(s)
      Kawase T, Hayama K, Tsuchimochi M, Nagata M, Okuda K, Yoshie H, Burns DM, Nakata K
    • Journal Title

      BIOPRESERVATION AND BIOBANKING

      Volume: 14 Issue: 2 Pages: 129-137

    • DOI

      10.1089/bio.2015.0072

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High resolution three-dimensional computed tomography analysis of the clinical efficacy of cultured autogenous periosteal cells in sinus lift bone grafting.2015

    • Author(s)
      Ogawa S, Hoshina H, Nakata K, Kazuho Y, Uematsu K, Kawase T, Takagi R, Nagata M
    • Journal Title

      Clin Implant Dent Relat Res.

      Volume: 2015 Issue: 4 Pages: 1-1

    • DOI

      10.1111/cid.12356

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 再生医療-新たな医療を求めて-Ⅲ 再生医療の臨床研究・治験 培養自家骨膜細胞シートを用いた歯槽骨・顎骨再生2015

    • Author(s)
      奥田一博, 永田昌毅, 高木律男, 中田 光, 吉江弘正
    • Journal Title

      日本臨牀

      Volume: 73 Pages: 473-478

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] インプラント患者の歯槽骨再生細胞療法の実際について2017

    • Author(s)
      永田昌毅
    • Organizer
      第16回日本再生医療学会 イブニングセミナー
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 病診連携により自家培養骨膜細胞を併用した上顎洞底挙上術を施行した1例2016

    • Author(s)
      山田一穂,星名秀行,倉嶋敏明,永田昌毅
    • Organizer
      第35回日本口腔インプラント学会関東甲信越支部会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Knowledge from a clinical trial of the use of cultured autogenous periosteal cells in gnathic bone regeneration and challenges for the future.2016

    • Author(s)
      Nagata M,Takagi R
    • Organizer
      The Special Lecture of our 3rd International Symposium in Kyung Hee University
    • Place of Presentation
      Seoul (Korea)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 培養自家骨膜による歯槽骨再生療法の臨床的取り組み2015

    • Author(s)
      小川 信,永田昌毅,星名秀行,山田一穂,高木律男
    • Organizer
      日本口腔インプラント学会近畿・北陸支部学術大会
    • Place of Presentation
      京都市、 京都大学百周年時計台記念館
    • Year and Date
      2015-01-31 – 2015-02-01
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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