Development of novel bone graft materials by combining scaffold-free cell construct and freeze dry technique
Project/Area Number |
26462969
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Osaka University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
今里 聡 大阪大学, 歯学研究科, 教授 (80243244)
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Research Collaborator |
YOSHIMOTO Itsumi
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 生体材料学 / 再生歯学 / 骨補填材 / 細胞集合体 / 歯学 / 組織工学 / 骨 |
Outline of Final Research Achievements |
The objective of this study was to develop the bone graft materials by combining scaffold-free cell construct fabrication system and freeze dry technique. With the usage of appropriate pretreatments, bone-like constructs, fabricated through osteoinduction of aggregate of bone marrow stromal cells, were able to maintain extracellular matrix and mineralized matrices even after being freeze-dried. The freeze-dried bone like constructs achieved in this study are expected to be used as a useful biomaterial for bone regenerative medicine.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Comparative Analysis of Mouse Induced Pluripotent Stem Cells and Mesenchymal Stem Cells during Osteogenic Differentiation in vitro.2014
Author(s)
Egusa, H., Kayashima, H., Miura, J., Uraguchi, S., Wang, F., Okawa, H., Sasaki, J.I., Saeki, M., Matsumoto, T., and Yatani, H.
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Journal Title
Stem cells and development.
Volume: 23
Issue: 18
Pages: 2156-2169
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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