Establishment of implant risk factor detection method by metabolome analysis
| Project/Area Number |
26462970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kobe University |
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Principal Investigator |
SUZUKI HIROAKI 神戸大学, 医学部附属病院, 講師 (10397812)
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| Co-Investigator(Kenkyū-buntansha) |
近津 大地 東京医科大学, 医学部, 教授 (30343122)
木本 明 神戸大学, 医学部附属病院, 特定助教 (30597167)
古森 孝英 神戸大学, 医学研究科, 教授 (50251294)
浅井 知子 神戸大学, 医学部附属病院, 特定助教 (90533745)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯科インプラント / リスクファクター / メタボローム解析 |
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| Outline of Final Research Achievements |
While implant treatment is becoming widespread, there are an increasing number of patients with various risk factors for treatment. However, there are currently no scientific indicators that can be clearly predicted and evaluated to detect them before surgery and whether treatment will proceed well. Therefore, we first established a novel implant experiment method using the rat mandible, and then produced a disease model rat (in this study, osteoporotic rats), which is considered to be a risk factor of implant treatment and carried out an implantation experiment. As a new analytical method, low molecular metabolic product separated from the blood of these rats were provided for metabolome analysis. As a result, we were able to identify substances that are likely candidates for novel biomarkers.
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Report
(5 results)
Research Products
(6 results)
