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A study for establishment of new periodontal/bone regenerative therapy by using BMP-9

Research Project

Project/Area Number 26462972
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionKagoshima University

Principal Investigator

Nakamura Toshiaki  鹿児島大学, 医歯学域附属病院, 講師 (60381183)

Co-Investigator(Kenkyū-buntansha) 白方 良典  鹿児島大学, 医歯学域歯学系, 准教授 (60359982)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsBMP-9 / 歯周病 / 骨再生 / 歯周組織再生 / 歯根膜細胞
Outline of Final Research Achievements

Periodontitis is an inflammatory disease resulting in tooth loss in patients. Further progress is needed in regeneration-based treatment of periodontal disease. In this study, basic research on periodontal regenerative therapy using bone morphogenetic protein (BMP)-9 was performed. As a result, (1) rhBMP-9 potently induces osteoblastic differentiation of human periodontal ligament (PDL) fibroblasts as compared with rhBMP-2. (2)rhBMP-9/ACS provided comparable new bone formation to rhBMP-2/ACS with less adipose tissues after a healing period of 8 weeks in rat calvarial critical-size defects. Further research investigating the potential of rhBMP-9 as a therapeutic agent for future oral and periodontal reconstructive procedures and medical fields is still necessary, and mechanisms underlying the effects of rhBMP-9 on periodontal/bone regeneration must be elucidated prior to clinical use in humans.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 5 results) Presentation (11 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Nova Southeastern University(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Comparison of the effects of recombinant human bone morphogenetic protein-2 and -9 on bone formation in rat calvarial critical-size defects.2017

    • Author(s)
      Nakamura T, Shirakata Y, Shinohara Y, Miron RJ, Hasegawa-Nakamura K, Fujioka-Kobayashi M, Noguchi K.
    • Journal Title

      Clin Oral Investig.

      Volume: 印刷中 Issue: 9 Pages: 2671-2679

    • DOI

      10.1007/s00784-017-2069-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Osteogenic potential of recombinant human bone morphogenetic protein-9/absorbable collagen sponge (rhBMP-9/ACS) in rat critical size calvarial defects.2017

    • Author(s)
      Toshiaki Nakamura, Yoshinori Shirakata, Yukiya Shinohara, Richard J. Miron, Kirara Furue, Kazuyuki Noguchi.
    • Journal Title

      Clinical Oral Investigations

      Volume: 印刷中 Issue: 5 Pages: 1659-1665

    • DOI

      10.1007/s00784-016-1963-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Involvement of PI3K/Akt signaling pathway in BMP9-stimulated osteogenic differentiation and SDF-1 production in human periodontal ligament fibroblasts2017

    • Author(s)
      Furue K, Sena K, Sakoda K, Nakamura T, Noguchi K.
    • Journal Title

      Eur J Oral Sci.

      Volume: 125(2) Issue: 2 Pages: 119-126

    • DOI

      10.1111/eos.12336

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Recombinant human bone morphogenetic protein-9 potently induces osteogenic differentiation of human periodontal ligament fibroblasts2016

    • Author(s)
      Sawako Fuchigami, Toshiaki Nakamura, Kirara Furue, Kotaro Sena, Yukiya Shinohara and Kazuyuki Noguchi
    • Journal Title

      European Journal of Oral Science

      Volume: 124 Issue: 2 Pages: 151-157

    • DOI

      10.1111/eos.12249

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects2016

    • Author(s)
      Yukiya Shinohara, Toshiaki Nakamura, Yoshinori Shirakata and Kazuyuki Noguchi
    • Journal Title

      Dental Materials Journal

      Volume: 35 Issue: 3 Pages: 454-460

    • DOI

      10.4012/dmj.2015-242

    • NAID

      130005155194

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 成長因子の歯周組織再生療法への応用について2016

    • Author(s)
      中村利明
    • Journal Title

      鹿児島大学歯学部紀要

      Volume: 36 Pages: 65-74

    • NAID

      120005758090

    • Related Report
      2015 Research-status Report
  • [Presentation] IL-1βはヒト歯根膜由来細胞のbone morphogenetic protein-9による骨芽細胞様分化を抑制する.2016

    • Author(s)
      江部由佳梨, 中村利明, 中村梢, 野口和行.
    • Organizer
      第59回秋季日本歯周病学会学術大会
    • Place of Presentation
      朱鷺メッセ 新潟コンベンションセンター (新潟県・新潟市)
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット頭蓋骨欠損におけるrhBMP-9 とrhBMP-2 の骨形成効果に対する比較研究.2016

    • Author(s)
      中村利明, 白方良典, 野口和行.
    • Organizer
      第46回公益社団法人日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋国際会議場 (愛知県・名古屋市)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Recombinant human bone morphogenetic protein-9/コラーゲン担体がラット頭蓋骨欠損の骨形成に及ぼす影響.2016

    • Author(s)
      篠原敬哉, 中村利明, 白方良典, 古江きらら, 野口和行.
    • Organizer
      第59回春季日本歯周病学会学術大会
    • Place of Presentation
      鹿児島県民交流センター (鹿児島県・鹿児島市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Bone morphogenetic protein 9 (BMP9)の歯根膜由来線維芽細胞の機能への影響.2016

    • Author(s)
      古江きらら, 瀬名浩太郎, 迫田 賢二, 中村利明, 野口 和行.
    • Organizer
      平成28年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      長崎県歯科医師会館 (長崎県・長崎市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラット頭蓋骨欠損モデルを用いたrecombinant human bone morphogenetic protein-9/コラーゲン担体の骨形成評価2015

    • Author(s)
      篠原 敬哉、中村 利明、白方良典、古江きらら、野口 和行
    • Organizer
      平成27年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      アクロス福岡(福岡県福岡市)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
  • [Presentation] New bone formation after application of recombinant human bone morphogenetic protein-9 with chitosan or collagen carrier in rat calvarial defects.2015

    • Author(s)
      Toshiaki Nakamura, Yoshinori Shirakata, Yukiya Shinohara and Kazuyuki Noguchi
    • Organizer
      Europerio 8
    • Place of Presentation
      ロンドン(イギリス)
    • Year and Date
      2015-06-03 – 2015-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] New bone formation after application of recombinant human bone morphogenetic protein-9 with chitosan or collagen carrier in rat calvarial defects.2015

    • Author(s)
      Toshiaki Nakamura, Yoshinori Shirakata, Yukiya Shinohara and Kazuyuki Noguchi
    • Organizer
      Europerio 8
    • Place of Presentation
      London, UK
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ラット頭蓋骨欠損におけるrecombinant human bone morphogenetic protein-9の骨形成効果2015

    • Author(s)
      篠原敬哉, 中村利明, 白方良典, 野口和行
    • Organizer
      第58回春季日本歯周病学会学術大会
    • Place of Presentation
      千葉 (幕張メッセ)
    • Year and Date
      2015-05-15 – 2015-05-16
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット頭蓋骨欠損におけるrecombinant human bone morphogenetic protein-9の骨形成効果2015

    • Author(s)
      篠原敬哉, 中村利明, 白方良典, 野口和行
    • Organizer
      第58回春季日本歯周病学会学術大会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Bone morphogenetic protein-9によるヒト歯根膜線維芽細胞の骨芽細胞様分化2014

    • Author(s)
      渕上 佐和子、中村 利明、篠原 敬哉、瀬名 浩太郎、古江 きらら、野口 和行
    • Organizer
      平成26年度日本歯周病学会九州五大学・日本臨床歯周病学会九州支部合同研修会
    • Place of Presentation
      福岡 (アクロス福岡)
    • Year and Date
      2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] BMP-9はヒト歯根膜線維芽細胞の新規の骨芽細胞様分化因子である2014

    • Author(s)
      桃嵜佐和子, 中村利明, 篠原敬哉, 瀬名浩太郎, 古江きらら, 野口和行
    • Organizer
      日本歯科保存学会2014年度春季学術大会(第140回)
    • Place of Presentation
      滋賀 (滋賀県立芸術劇場)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-02-16  

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