| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Periodontitis is an inflammatory disease resulting in tooth loss in patients. Further progress is needed in regeneration-based treatment of periodontal disease. In this study, basic research on periodontal regenerative therapy using bone morphogenetic protein (BMP)-9 was performed. As a result, (1) rhBMP-9 potently induces osteoblastic differentiation of human periodontal ligament (PDL) fibroblasts as compared with rhBMP-2. (2)rhBMP-9/ACS provided comparable new bone formation to rhBMP-2/ACS with less adipose tissues after a healing period of 8 weeks in rat calvarial critical-size defects. Further research investigating the potential of rhBMP-9 as a therapeutic agent for future oral and periodontal reconstructive procedures and medical fields is still necessary, and mechanisms underlying the effects of rhBMP-9 on periodontal/bone regeneration must be elucidated prior to clinical use in humans.
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