| Project/Area Number |
26462978
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
|
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| Research Institution | Tohoku University (2015-2016)
Tokyo Dental College (2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
櫻井 薫 東京歯科大学, 歯学部, 教授 (20153950)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 線維芽細胞 / 歯肉 / ナノテクノロジー / チタン / 表面改質 / 結合組織 / 生体模倣 / ナノ形状 / インプラント周囲組織 / 結合組織性付着 / 歯肉線維 |
|---|
| Outline of Final Research Achievements |
One disadvantage of titanium implants effective for reconstruction of dental / maxillofacial defects is that they do not adhere to the connective tissue layer of the gingival tissue and skin. The purpose of this study is to develop titanium implants adhering to connective tissue by forming nano-topography on titanium surface using alkali-heat treatment.
Titanium surface subjected to alkali-heat treatment under specified conditions exhibited nano-topography characterized by numerous nano-pores and dense nano-spikes. The nano-titanium surface increased the amount of collagen production from rat gingival and human dermal fibroblasts and the adhesion strength of extracellular matrix. In the rabbit maxilla model, it was demonstrated that the nano-titanium surface implant encapsulated the end of gingival fiber within the surface and acquired periodontal-like like connective tissue attachment.
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