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Analyzed stem cell differentiation and regeneration property treated by non steroidal anti-inflammatory agent

Research Project

Project/Area Number 26462981
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionThe Nippon Dental University

Principal Investigator

Tsutsui Takeo  日本歯科大学, 生命歯学部, 教授 (70366764)

Co-Investigator(Kenkyū-buntansha) 中原 貴  日本歯科大学, 生命歯学部, 教授 (10366768)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords歯髄幹細胞 / 歯根膜細胞 / 非ステロイド性抗炎症薬 / アスピリン / NSAIDs / 幹細胞 / 分化誘導 / 酸性非ステロイド性抗炎症薬 / 歯根膜幹細胞
Outline of Final Research Achievements

We analyzed stem cell property that treated with non steroidal anti-inflammatory agent (NSAIDs) using mouse dental pulp cells, human dental pulp stem cells and human periodontal ligament cells. Differentiation potential analyzed by treated with high dose or low dose aspirin. Cultured in osteogenic and adipogenic differentiation medium, prompt positive staining reveled in treated with high dose aspirin. When cultured in adipogenic medium, prompt positive staining reveled in treated with high dose aspirin.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] ヒト歯髄幹細胞とヒト歯根膜細胞の分化能へのアスピリン作用の解析2016

    • Author(s)
      筒井健夫, 小林朋子, 鳥居大祐, 松井美紀子, 中原 貴
    • Organizer
      歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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