Stem cells for bone regeneration in the jaw bone

• Project/Area Number: 26462990
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: Tei Kanchu 北海道大学, 歯学研究科, 教授 (80180066)
• Co-Investigator(Kenkyū-buntansha): 菊入 崇 北海道大学, 歯学研究科, 助教 (10322819) ; 吉村 善隆 北海道大学, 歯学研究科, 准教授 (30230816)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯学 / 間葉系幹細胞

Outline of Final Research Achievements

This study aimed to demonstrate the usefulness of bone marrow derived mesenchymal stem cells (MSCs) in jaw bone reconstruction.In transplant experiments in mice, we demonstrated that transplantation of MSCs and HSCs led to the induction of bone formation and contributed to the replacement of carriers in the grafts by bone tissue.It was suggested that HSCs in the graft enhance bone formation from MSCs by sending multiple signals to MSCs.In this study, we were able to obtain important cell biological findings on the mechanism underlying the differentiation of MSCs.