Study on target of cancer immunoediting in oral cancer

• Project/Area Number: 26462992
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hirosaki University
• Principal Investigator: Sakaki Hirotaka 弘前大学, 医学研究科, 客員研究員 (90374850)
• Co-Investigator(Kenkyū-buntansha): 松宮 朋穂 弘前大学, 医学研究科, 助教 (30344592)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 口腔癌 / 細胞周期 / 自然免疫 / 癌 / 口腔

Outline of Final Research Achievements

Little report regarding immunotherapy for oral cancer has been shown. Since Oral immune tolerance has been proposed, we focused on the effect of innate immune system-associated factors in ant-tumor effect in oral cancer. We initially generated Fucci-expressing oral cancer cell line to evaluate cell cycle. Using this cell line, we found that little individual immune-related factor altered cell cycle distribution in response to anticancer reagents. However, we also observed that multiple immune-related factors did affect the cell cycle distribution altered by the anticancer drugs, indicating that immune-related factors may alter the anticancer effect in oral cancer.

Research Products

• [Journal Article] Can Superselective Intra-Arterial Chemoradiotherapy Replace Surgery Followed by Radiation for Advanced Cancer of the Tongue and Floor of the Mouth? (2016)
  • Author(s): Kobayashi W, Kukobota K, Ito R, Sakaki H, Nakagawa H, Teh BG.
  • Journal Title: J Oral Maxillofac Surg Volume: 74 Issue: 6 Pages: 1248-54
  • DOI: 10.1016/j.joms.2016.01.007
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Identification of a point mutation in the SH3BP2 gene in cherubism (2015)
  • Author(s): Sakaki H, Matsumiya T, Furudate F, Kobayashi W, Kon T, Itoh R, Kimura H
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 27 Issue: 6 Pages: 880-3
  • DOI: 10.1016/j.ajoms.2015.03.007
  • Peer Reviewed
• [Journal Article] Professional oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer. (2015)
  • Author(s): Kubota K, Kobayashi W, Sakaki H, Nakagawa H, Kon T, Mimura M, Ito R, Furudate K, Kimura H
  • Journal Title: Support Care Cancer. Volume: 23 Issue: 11 Pages: 3323-3329
  • DOI: 10.1007/s00520-015-2774-x
  • Peer Reviewed
• [Journal Article] Sjogren's syndrome with marked swelling of major salivary glands related to localized AL amyloidosis: A case report and literature review (2015)
  • Author(s): Kubota K, Furudate K, Nakagawa K,Sakaki H, Kobayashi W, Kimura H
  • Journal Title: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology Volume: 27 Issue: 4 Pages: 518-21
  • DOI: 10.1016/j.ajoms.2014.09.003
  • Peer Reviewed
• [Presentation] ケルビズムの1例 (2014)
  • Author(s): 榊 宏剛、古舘 健、松宮 朋穂、伊藤 良平、小林 恒 、木村 博人
  • Organizer: 第59回(公社)日本口腔外科学会総会・学術大会
  • Place of Presentation: 千葉 幕張メッセ
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Identifying a point mutation in the SH3BP2 gene in cherubism (2014)
  • Author(s): Hirotaka Sakaki, Ken Furudate, Tomoh Matsumiya, Hisashi Sato, Ryohei Itoh, Wataru Kobayashi, Hiroto Kimura
  • Organizer: 96th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons
  • Place of Presentation: USA Hawaii
  • Year and Date: 2014-09-08 – 2014-09-13