| Project/Area Number |
26462994
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
椎葉 正史 千葉大学, 大学院医学研究院, 准教授 (20301096)
鵜澤 一弘 千葉大学, 大学院医学研究院, 准教授 (30302558)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | MyoD family 遺伝子 / 脂肪幹細胞 / 筋再生 / MyoD family遺伝子 |
|---|
| Outline of Final Research Achievements |
Myocutaneous flaps are clinically used for reconstruction of tissue defect, which is caused by the operations for oral cancer. However, restricted movement and power reduction of muscle frequently occurred. In this study, we tried to regenerate muscle cells from several kinds of cells, such as human adipose derived stem cell, human fatal fibroblast, and human bone marrow stem cell, by induction of MyoD family and Pax-7 genes, which are important for muscle differentiation. In the transfectants, α-actinin and α-SMA, two specific markers of myogenesis, were detected, suggesting that MyoD family and Pax-7 genes might be important factors of regeneration of muscle.
|
