| Project/Area Number |
26463000
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川口 知子 (武田知子 / 川口 知子(武田知子)) 岐阜大学, 医学部附属病院, 医員 (30509815)
飯田 一規 岐阜大学, 大学院医学系研究科, 助教 (30585237)
玉置 也剛 岐阜大学, 大学院医学系研究科, 助教 (40585303)
柴田 敏之 岐阜大学, 大学院医学系研究科, 教授 (50226172)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯髄細胞 / iPS細胞 / ヒト歯髄細胞 |
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| Outline of Final Research Achievements |
Although the involvement of DLX4 has been clarified as a factor involved in the efficiency of inducing iPS cells among different dental pulp cell lines, as a result of DNA microarray between different cell lines expressing this factor, one factor is cited. We also found that the expression of DLX4 can suppress the expression of DLX4 by treating dental pulp cells with TGF-beta, but as a result of investigating this intracellular signaling system, ERK, p38 MAPK, Akt activation was confirmed. Therefore, when investigating the involvement of the factor expression specified in the DNA microarray in these pathways, the involvement of the Akt pathway was suggested.
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