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Nicotine Induces Lymph Node Metastasis of Oral Cancer Cells through EGFR Activation

Research Project

Project/Area Number 26463004
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

IBARAGI Soichiro  岡山大学, 医歯薬学総合研究科, 助教 (80549866)

Co-Investigator(Kenkyū-buntansha) 佐々木 朗  岡山大学, 医歯薬学総合研究科, 教授 (00170663)
Research Collaborator Hassan Mohammad Monsur  Charles Sturt University, School of Dentistry & Health Sciences
Hu Guo-Fu  Molecular Oncology Research Institute, Tufts Medical Center
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsニコチン / EGFR / リンパ管新生 / 口腔癌
Outline of Final Research Achievements

Nicotine, which is one of the main component of tobacco, is absorbed from oral mucosa and pulmonary alveoli by smoking, and moves to blood. Nicotine in blood binds to nicotinic acetylcholine receptor (nAChR) in central nervous system and relates to tobacco addiction. Recently, it has been reported that nicotine promotes proliferation and invasion in breast cancer cells through epidermal growth factor receptor (EGFR) activation. However, the role of nicotine in oral cancer cells is still unknown although oral cavity is most exposed organ to tobacco smoke. Therefore, this study assessed the effects of nicotine on oral cancer cells. Nicotine increased lymph node metastasis of oral cancer cells in animal model.The mechanism underlying the tumor progressive effects of nicotine in oral cancer cells consists of upregulation of cell proliferation, migration and invasion via the activation of EGFR.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (3 results) Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Tufts Medical Center(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Charles Sturt University(オーストラリア)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Tufts Medical Center/Molecular Oncology Research Institute(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Expression and Roles of CCN2 in Dental Epithelial Cells2015

    • Author(s)
      Shimo T, Koyama E, Kurio N, Matsumoto K, Okui T, Ibaragi S, Yoshioka N, Sasaki A.
    • Journal Title

      In Vivo

      Volume: 29 Pages: 189-195

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthetic (+)-terrein suppresses interleukin-6/soluble interleukin-6 receptor induced-secretion of vascular endothelial growth factor in human gingival fibroblasts.2014

    • Author(s)
      Mandai H, Omori K, Yamamoto D, Tsumura T, Murota K, Yamamoto S, Mitsudo K, Ibaragi S, Sasaki A, Maeda H, Takashiba S, Suga S.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 22 Pages: 5338-44

    • Related Report
      2014 Research-status Report
  • [Journal Article] Neamine Inhibits Oral Cancer Progression by Suppressing Angiogenin-mediated Angiogenesis and Cancer Cell Proliferation」2014

    • Author(s)
      Kishimoto K Yoshida S, Ibaragi S, Yoshioka N, Hu GF, Sasaki A.
    • Journal Title

      Anticancer Research

      Volume: 34 Pages: 2113-21

    • Related Report
      2014 Research-status Report
  • [Presentation] Nicotine Induces Lymph Node Metastasis of Oral Cancer Cells through EGFR Activation2017

    • Author(s)
      Soichiro Ibaragi; Shinichi Kodama; Daisuke Kuwajima; Tatsuo Okui; Norie Yoshioka; Tsuyoshi Shimo; Akira Sasaki
    • Organizer
      6th World Oral Cancer Congress of the International Academy of Oral Oncology (IAOO)
    • Place of Presentation
      インド
    • Year and Date
      2017-05-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔癌細胞におけるニコチンと上皮成長因子受容体の関連性について2016

    • Author(s)
      桑島大介,伊原木聰一郎,高畠清文,吉岡徳枝,岸本晃治,志茂 剛,長塚 仁,佐々木 朗
    • Organizer
      第70回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔癌細胞におけるニコチンと上皮成長因子受容体の関連性について2016

    • Author(s)
      桑島大介,伊原木聰一郎,高畠清文,吉岡徳枝,岸本晃治,志茂 剛,長塚 仁,佐々木 朗
    • Organizer
      第70回 NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2022-02-16  

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