Function of Heme oxygenase-1 induced from oral mucosal cells and the role for oral candidiasis

• Project/Area Number: 26463007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Kouji Ohta 広島大学, 病院(歯), 助教 (20335681)
• Co-Investigator(Kenkyū-buntansha): 武知 正晃 広島大学, 医歯薬保健学研究院(歯), 准教授 (00304535) ; 重石 英生 広島大学, 医歯薬保健学研究院(歯), 助教 (90397943)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ヘムオキシゲナーゼ1 (HO-1) / 口腔粘膜細胞 / 口腔カンジダ症 / HO-1 / Heme oxygenase I / 口腔candida 症 / Candida 症

Outline of Final Research Achievements

Oral mucosa may regulate stress response against Candida. We focused on Heme oxygenase-1 (HO-1) gene induced by Candida albicans (Ca), and investigated the HO-1 expression oral keratinocytes. We found HO-1 expression induced by heat-killed Ca using a cDNA microarray. beta-glucan derived from Ca increased HO-1 expression in oral keratinocytes. beta-glucans promoted induction of intercellular reactive oxygen species and Nrf2 translocation into nuclei. HO-1 induced by beta-glucan may have an important role in host defense against the stress caused by C. albicans.

Research Products

• [Presentation] 口腔粘膜上皮細胞におけるCandida albicans によるHemeoxygenase-1誘導とシグナル伝達 (2014)
  • Author(s): 石田陽子，太田耕司，鳴瀬貴子，福井暁子，西裕美，奥井岳，武知正晃
  • Organizer: 第59回日本口腔外科学会総会・学術大会
  • Place of Presentation: 幕張メッセ，国際会議場，東京
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] 口腔粘膜上皮細胞におけるCandida albicansによるROS-Nrf2経路を介したHemooxygenase-1の発現誘導 (2014)
  • Author(s): 石田陽子，太田耕司，鳴瀬貴子，福井暁子，西裕美，奥井岳，武知正晃
  • Organizer: 第24回日本口腔内科学会・第27回日本口腔診断学会合同学術大会
  • Place of Presentation: 九州大学医学部百年講堂，福岡
  • Year and Date: 2014-09-18 – 2014-09-20