Function of Heme oxygenase-1 induced from oral mucosal cells and the role for oral candidiasis
Project/Area Number |
26463007
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | Hiroshima University |
Principal Investigator |
Kouji Ohta 広島大学, 病院(歯), 助教 (20335681)
|
Co-Investigator(Kenkyū-buntansha) |
武知 正晃 広島大学, 医歯薬保健学研究院(歯), 准教授 (00304535)
重石 英生 広島大学, 医歯薬保健学研究院(歯), 助教 (90397943)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | ヘムオキシゲナーゼ1 (HO-1) / 口腔粘膜細胞 / 口腔カンジダ症 / HO-1 / Heme oxygenase I / 口腔candida 症 / Candida 症 |
Outline of Final Research Achievements |
Oral mucosa may regulate stress response against Candida. We focused on Heme oxygenase-1 (HO-1) gene induced by Candida albicans (Ca), and investigated the HO-1 expression oral keratinocytes. We found HO-1 expression induced by heat-killed Ca using a cDNA microarray. beta-glucan derived from Ca increased HO-1 expression in oral keratinocytes. beta-glucans promoted induction of intercellular reactive oxygen species and Nrf2 translocation into nuclei. HO-1 induced by beta-glucan may have an important role in host defense against the stress caused by C. albicans.
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Report
(4 results)
Research Products
(2 results)