| Project/Area Number |
26463012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kochi University |
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Principal Investigator |
SASABE Eri 高知大学, 教育研究部医療学系臨床医学部門, 講師 (40363288)
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| Co-Investigator(Kenkyū-buntansha) |
山本 哲也 高知大学, 教育研究部医療学系臨床医学部門, 教授 (00200824)
北村 直也 高知大学, 教育研究部医療学系臨床医学部門, 講師 (70351921)
村田 智子 高知大学, 教育研究部医療学系, 助教 (00610916)
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| Research Collaborator |
TOMITA Riki 高知大学, 医学部, 大学院生 (90759416)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腫瘍関連マクロファージ / 口腔扁平上皮癌 / 抗がん剤 / 抗癌剤 |
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| Outline of Final Research Achievements |
We investigated whether tumor-associated macrophages (TAM) are involved in the mechanism of acquired chemoresistance in oral squamous-cell carcinoma (OSCC). As a result, it was revealed that exosomes secreted by TAM promotes the proliferative capacity of OSCC cells and reduces the anti-cancer drug sensitivity through regulation of the cell cycle and suppression of apoptosis. Therefore, it was suggested that TAM may decrease sensitivity to anti-cancer drugs through secretion of exosomes in the tumor microenvironment.
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