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A study of immune cell network involved in pathogenesis of oral lichen planus

Research Project

Project/Area Number 26463013
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

HAYASHIDA JUN-NOSUKE  九州大学, 歯学研究院, 助教 (80432920)

Co-Investigator(Kenkyū-buntansha) 中村 誠司  九州大学, 歯学研究院, 教授 (60189040)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords口腔扁平苔癬 / サイトカイン / T細胞 / Th2タイプサイトカイン / ヘルパーT細胞
Outline of Final Research Achievements

Helper T (Th) 1, Th 2 of oral lichen planus (OLP) are pay attention to Th 17 and regulatory T cells (Treg) which have recently been reported to be associated with pathogenesis in autoimmune diseases and chronic inflammatory diseases. We also performed to research on those Th subsets.
Expression of Th1, Th2 and Th17 type related molecules was enhanced in OLP patients compared with healthy subjects. In addition to the basal layer with marked hyperkeratosis, IL-23 showed to express in all epithelial layers and lymphocytes immediately beneath the epithelium. Also, expression of Th2 type IL-33 was found in the basal layer of the mucosa. TSLP as Th2-related molecule was identified and expression was found in the basal layer of the mucosa. And so, we published the result of the research.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2015

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results)

  • [Journal Article] Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus2017

    • Author(s)
      Yamauchi M, Moriyama M, Hayashida JN, Maehara T, Ishiguro N, Kubota K, Furukawa S, Ohta M, Sakamoto M, Tanaka A, Nakamura S
    • Journal Title

      PLoS One

      Volume: 12(3) Issue: 3 Pages: e0173017-e0173017

    • DOI

      10.1371/journal.pone.0173017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cytokine profiles contribute to understanding the pathogenic difference between Good syndrome and oral lichen planus: two case reports and literature review2015

    • Author(s)
      Maehara T, Moriyama M, Kawano S, Hayashida JN, Furukawa S, Ohta M, Tanaka A, Yamauchi M, Ohyama Y, Kiyoshima T, Nakamura S.
    • Journal Title

      Medicine (Baltimore)

      Volume: 94(14) Issue: 14 Pages: e704-e704

    • DOI

      10.1097/md.0000000000000704

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differences of Stimulated and Unstimulated Salivary Flow Rates in The Patients with Dry Mouth2015

    • Author(s)
      Jun-Nosuke Hayashida∗, Sakae Minami, Masafumi Moriyama, et al
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 27 Pages: 96-101

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Detection of Maternal–Fetal Microchimerism in patients with Oral Lichen Planus2015

    • Author(s)
      Jun-Nosuke Hayashida, Masafumi Moriyama, Takeshi Toyoshima, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, and Seiji Nakamura
    • Journal Title

      Oral Science in Japan

      Volume: 1 Pages: 91-94

    • NAID

      40021070520

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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