A study of immune cell network involved in pathogenesis of oral lichen planus
Project/Area Number |
26463013
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
|
Research Institution | Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
中村 誠司 九州大学, 歯学研究院, 教授 (60189040)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 口腔扁平苔癬 / サイトカイン / T細胞 / Th2タイプサイトカイン / ヘルパーT細胞 |
Outline of Final Research Achievements |
Helper T (Th) 1, Th 2 of oral lichen planus (OLP) are pay attention to Th 17 and regulatory T cells (Treg) which have recently been reported to be associated with pathogenesis in autoimmune diseases and chronic inflammatory diseases. We also performed to research on those Th subsets. Expression of Th1, Th2 and Th17 type related molecules was enhanced in OLP patients compared with healthy subjects. In addition to the basal layer with marked hyperkeratosis, IL-23 showed to express in all epithelial layers and lymphocytes immediately beneath the epithelium. Also, expression of Th2 type IL-33 was found in the basal layer of the mucosa. TSLP as Th2-related molecule was identified and expression was found in the basal layer of the mucosa. And so, we published the result of the research.
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Report
(4 results)
Research Products
(4 results)
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[Journal Article] Myeloid dendritic cells stimulated by thymic stromal lymphopoietin promote Th2 immune responses and the pathogenesis of oral lichen planus2017
Author(s)
Yamauchi M, Moriyama M, Hayashida JN, Maehara T, Ishiguro N, Kubota K, Furukawa S, Ohta M, Sakamoto M, Tanaka A, Nakamura S
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Journal Title
PLoS One
Volume: 12(3)
Issue: 3
Pages: e0173017-e0173017
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cytokine profiles contribute to understanding the pathogenic difference between Good syndrome and oral lichen planus: two case reports and literature review2015
Author(s)
Maehara T, Moriyama M, Kawano S, Hayashida JN, Furukawa S, Ohta M, Tanaka A, Yamauchi M, Ohyama Y, Kiyoshima T, Nakamura S.
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Journal Title
Medicine (Baltimore)
Volume: 94(14)
Issue: 14
Pages: e704-e704
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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