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A study on the mechanism of invasion and metastasis thorough epithelial-mesenchymal transition in oral squamous cel carcinoma

Research Project

Project/Area Number 26463014
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

Kawano Shintaro  九州大学, 大学病院, 講師 (00398067)

Co-Investigator(Kenkyū-buntansha) 豊嶋 健史  九州大学, 歯学研究院, 共同研究員 (20546569)
中村 誠司  九州大学, 歯学研究院, 教授 (60189040)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords浸潤 / 転移 / 口腔癌 / 上皮間葉転換 / ZEB1 / ZEB2 / deltaNp63 / 口腔扁平上皮癌 / ZEBファミリー / ΔNp63 / miR205 / 上皮-間葉転換
Outline of Final Research Achievements

Previously, microRNA (miR) microarray analyses were performed to identify the responsible gene for epithelial-mesenchymal transition ( EMT)mediated by ΔNp63β in oral squamous cell carcinoma (OSCC). As the results, we focused on miR-205 that is up-regulated by ΔNp63β-forced expression. The inhibitor for miR-205 was thus added into the culture supernatant of OSCC cells strongly expressingΔNp63β. And then, expression of zinc finger E-box binding homeobox (ZEB)1 and ZEB2 was up-regulated, epithelial markers including cytokeratin 19 and E-cadherin were also down-regulated, mesenchymal markers were up-regulated. Furthermore, capacities of invasion and migration were enhanced by the treatment of inhibitor for miR-205. These results showed tumor-suppressive roles of ΔNp63β and miR-205 by inhibiting EMT thorough modulating ZEB1 and ZEB2 expressions in OSCC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 Other

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] Critical roles of Wnt5a-Ror2 signaling in aggressiveness of oral squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition2017

    • Author(s)
      Taiki Sakamoto, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Taichi Hattori, Shoichi Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura,
    • Journal Title

      Oral Oncology

      Volume: 69 Pages: 15-25

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma2016

    • Author(s)
      Kawano S, Zheng Y, Oobu K, Matsubara R, Goto Y, Chikui T, Yoshitake T, Kiyoshima T, Jinno T, Maruse Y, Mitate E, Kitamura R, Tanaka H, Toyoshima T, Sugiura T, Nakamura S
    • Journal Title

      Oncology letters

      Volume: 11 Pages: 3369-3376

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.2015

    • Author(s)
      Jinno T, Kawano S, Maruse Y, Matsubara R, Goto Y, Sakamoto T, Hashiguchi Y, Kaneko N, Tanaka H, Kitamura R, Toyoshima T, Jinno A, Moriyama M, Oobu K, Kiyoshima T, Nakamura S.
    • Journal Title

      Oncol Rep

      Volume: 33 Issue: 5 Pages: 2161-2168

    • DOI

      10.3892/or.2015.3838

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation.2015

    • Author(s)
      Maruse Y, Kawano S, Kiyoshima T, Goto Y, Matsubara R, Chikui T, Yoshiga D, Nakamura S.
    • Journal Title

      Head and Neck

      Volume: 印刷中 Issue: 11 Pages: E161-E164

    • DOI

      10.1002/hed.24036

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 口腔扁平上皮癌におけるkallikrein related peptidase 6の発現と機能に関する研究2017

    • Author(s)
      金子直樹、川野真太郎、松原良太、後藤雄一、神野哲平、丸瀬靖之、坂本泰基、橋口有真、松村万由、服部多市、田中秀明、大部一成、中村誠司
    • Organizer
      第35回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2017-01-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるmiR-205の発現と機能に関する研究~特にΔNp63との関連について~2016

    • Author(s)
      橋口有真、川野真太郎、後藤雄一、松原良太、神野哲平、丸瀬靖之、金子直樹、坂本泰基、松村万由、中村誠司
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の遊走能におけるΔNp63を介したWnt5a-Ror2シグナル経路の関与2016

    • Author(s)
      坂本泰基、川野真太郎、松原良太、後藤雄一、神野哲平、丸瀬靖之、金子直樹、橋口有真、中村誠司
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるkallikrein related peptidase 6の発現と機能に関する研究2016

    • Author(s)
      金子直樹、川野真太郎、松原良太、後藤雄一、神野哲平、丸瀬靖之、坂本泰基、橋口有真、松村万由、中村誠司
    • Organizer
      第70回日本口腔科学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌におけるΔNp63を介した浸潤・転移の分子機構に関する研究~Wnt5a-Ror2シグナル経路との関連~2016

    • Author(s)
      坂本泰基、川野真太郎、松原良太、後藤雄一、神野哲平、丸瀬靖之、金子直樹、橋口有真、大部一成、中村誠司
    • Organizer
      第34回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] PD-1/PD-L1 coexpression is associated with poor prognosis in the oral squamous cell carcinoma patients2015

    • Author(s)
      Y. Maruse, S. Kawano, R. Matsubara, Y. Goto, T. Jinno, N. Kaneko, T. Sakamoto, Y. Hashiguchi, K. Oobu, S. Nakamura
    • Organizer
      第63回国際歯科研究学会(JADR)総会・学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] A study on the expression and function of interleukin-6 in oral squamous cell carcinoma ~its possible involvement in chemotherapeutic resistance~2015

    • Author(s)
      T. Jinno, S. Kawano, R. Matsubara,Y. Maruse, T. Sakamoto, Y. Hashiguchi, N. Kaneko, A. Jinno, M. Morioka, K. Oobu, T. Kiyoshima, S. Nakamura.
    • Organizer
      第39回日本頭頸部癌学会 第4回アジア頭頸部癌学会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinicopathological evaluation of preoperative chemoradiotherapy with S-1 for locally advanced OSCC2015

    • Author(s)
      Y. Hashiguchi, S. Kawano, K. Oobu, R. Matsubara, Y. Goto, T. Jinno, Y. Maruse, T. Sakamoto, N. Kaneko, M. Morioka, S. Nakamura.
    • Organizer
      第39回日本頭頸部癌学会 第4回アジア頭頸部癌学会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-06-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 根治的頸部郭清術2015

    • Author(s)
      川野 真太郎
    • Organizer
      第33回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      奈良市
    • Year and Date
      2015-01-29 – 2015-01-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 九州大学大学院歯学研究院口腔顎顔面病態学講座顎顔面腫瘍制御学分野

    • URL

      http://www.omfs1.dent.kyushu-u.ac.jp

    • Related Report
      2016 Annual Research Report
  • [Remarks] 九州大学大学院歯学研究院 顎顔面腫瘍制御学分野ホームページ

    • URL

      http://www.omfs1.dent.kyushu-u.ac.jp

    • Related Report
      2015 Research-status Report
  • [Remarks] 九州大学 研究者情報

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K002902/research.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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