Immune function analysis of BRONJ mouse model and development of prophylactic therapy using regulatory T cells.
| Project/Area Number |
26463016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University (2015-2016)
Nagasaki University (2014) |
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Principal Investigator |
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| Research Collaborator |
NAKAMURA Seiji
ASAHINA Izumi
SUMITA Yoshinori
KUROSHIMA Shinichiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | BRONJ / ARONJ / MRONJ / 骨吸収抑制薬 / ビスフォスフォネート / 抗RANKL抗体 / 制御性T細胞 / 顎骨壊死 / 骨粗鬆症 / 樹状細胞 / 制御性Ｔ細胞 / 制御性 T 細胞 |
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| Outline of Final Research Achievements |
In order to investigate the relationship between BRONJ occurrence risk and immune function, we first planned to create model mice with different BRONJ occurrence risk. The four model mice used in this study are planned to be prepared in accordance with the past method, and because there is some already established by research collaborators, we have matched the mouse with this study. We also plan to investigate the immune function of each mouse, 1) investigate the tissue localization of DC using immunohistochemical staining method, 2) stage to establish DC preparation method from peripheral blood .
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Report
(4 results)
Research Products
(12 results)
