| Project/Area Number |
26463022
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
武田 啓 北里大学, 医学部, 教授 (20197297)
杉本 孝之 北里大学, 医学部, 講師 (20365133)
熊澤 憲一 北里大学, 医学部, 講師 (60383618)
馬場 香子 北里大学, 医学部, 特別研修生 (90327411)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 未分化間葉系細胞 / 凍結保存 / 再生医工学 |
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| Outline of Final Research Achievements |
By the animal experiment of the skull defect model, that amount of ossification became the following order: scaffold,< supernatant +scaffold, <supernatant (10X) +scaffold, < hBMC+scaffold. From this result、we thought that the bone regeneration therapy by using mesenchymal cells would be limited to the bone defect for which the continuous growth factors were needed. According to the circumstances (a general status, age, base conditions, etc.) of the bone defect of recipient, it was suggested that we could select the hybird type bone substitute, for example conditioned medium alone or a concentrated conditioned medium, further hBMC.
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