| Project/Area Number |
26463024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河野 通秀 東京医科大学, 医学部, 助教 (00421066)
近津 大地 東京医科大学, 医学部, 教授 (30343122)
渡辺 正人 東京医科大学, 医学部, 臨床講師 (40349460)
虻川 東嗣 明海大学, 歯学部, 准教授 (50453717)
藤川 考 東京医科大学, 医学部, 兼任助教 (60322468)
長尾 俊孝 東京医科大学, 医学部, 主任教授 (90276709)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 顎骨浸潤 / 腫瘍関連マクロファージ / 口腔癌 |
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| Outline of Final Research Achievements |
The cytokine colony stimulating factor-1(CSF-1) is an important factor of tumor associated macrophage (TAM) recruitment and differentiation and several pharmacological agents targeting the CSF-1 receptor (CSF-1R) have been developed to regulate TAM in solid cancers. Although single CSF-1R inhibition only modestly delayed tumor growth, combination with mTOR promoted the control of tumor outgrowth. The mTOR decreased VEGFR mRNA expression and the mRNA expressions RANKL and CSF-1R decreased in CSF-1R inhibition in bone invasion by oral squamous cell carcinoma (OSCC). CSF-1R inhibition can suppress osteoclast mediated bone invasion by OSCC.
We suggest that combination treatment of mTOR with CSF-1R inhibition might be expected to be a therapeutic target to prevent bone invasion by OSCC. Our data support further development of treatments combining mTOR with TAM targeting agents.
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