| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the role of cystatin in the salivary secretion observed in a Sjogren's syndrome patient.
The secretion of salivary cystatin significantly decreased in the Sjogren's syndrome patient significantly. In Sjogren's syndrome patients, there were many TUNEL positive cells tend to be observed in the serous and mucous acinar cells of the labial glands. The more morphological change that is observed, the less cystatin S intensity that is seen in the serous demilunes of the salivary gland. TheAn inhibition of apoptosis was observed when cystatin S was added to the apoptosis-induced cultured HSG cells.
These results suggested that one of the causes of hyposalivation in Sjogren's syndrome is likelywas the failure of the apoptotic control function by cystatin, and thus the administration of applying cystatin S may have allowed the patient to overcome this problempossibly controlled the failure.
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