Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Outline of Final Research Achievements |
When clenching the teeth, compressive force is applied directly to the synovium in the disc, causing synovitis of temporomandibular disorders (TMJ disc derangement). We have developed a novel synovitis model using a cyclic loading bioreactor, and cultured human synovial cells in a 3D cell-scaffold construct. We studied pharmaceutical agents for temporomandibular disorders by using this model. This system can asses the effects of pharmaceutical agents for TMD in vitro.
|