Pharmaceutical therapeutic assesment for temporomanidibular disorders by using sinovitis model of human TMJ in vitro
| Project/Area Number |
26463034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
KAKUDO Kenji 大阪歯科大学, 歯学部, 名誉教授 (30131379)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKATA Ken 大阪大学, 医学研究科(研究院), 教授 (00283747)
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| Research Collaborator |
KONDO Mayo
YATANI Shinya
OKAMOTO Tomoko
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 顎関節症 / 薬物療法 / 滑膜炎 / PRP / 顎関節 / 滑膜細胞 / 多血小板血漿 / ヒト / 滑膜炎モデル / 抗炎症性鎮痛薬 / 三次元培養 / 圧縮負荷 / 金属プロテアーゼ |
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| Outline of Final Research Achievements |
When clenching the teeth, compressive force is applied directly to the synovium in the disc, causing synovitis of temporomandibular disorders (TMJ disc derangement). We have developed a novel synovitis model using a cyclic loading bioreactor, and cultured human synovial cells in a 3D cell-scaffold construct. We studied pharmaceutical agents for temporomandibular disorders by using this model. This system can asses the effects of pharmaceutical agents for TMD in vitro.
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Report
(4 results)
Research Products
(7 results)
