• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis on glycogen metabolism in oral squamous cell carcinoma

Research Project

Project/Area Number 26463040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionShinshu University

Principal Investigator

KURITA Hiroshi  信州大学, 学術研究院医学系, 教授 (10273103)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsグリコーゲン / 口腔扁平上皮癌 / 代謝 / 解糖系 / グリコーゲン代謝 / 糖代謝 / ペントースリン酸経路 / 口腔癌
Outline of Final Research Achievements

It is thought that the glycogen is one of key sources in supplying energy, nucleic acid, and lipid necessary for cancer cell proliferation in oral squamous cell carcinoma. The purpose of this study is to analyze metabolism of glycogen and to elucidate metabolism abnormality in oral squamous cell carcinoma. The results of this study suggested that oral squamous cell carcinoma cell got energy not simply in the glycolytic pathway, a simple course called the glycogen → glucose → glycolytic pathway, and they also suggested the possibility that oral squamous cell carcinoma might get energy by amino acid metabolism. It will be necessary to examine the metabolism of amino acid, glucuronic acid, and nucleic acids etc., and to analyze the specificity in the metabolism of oral squamous cell carcinoma.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Estimation of the width of free margin with a significant impact on local recurrence in surgical resection of oral squamous cell carcinoma2016

    • Author(s)
      Yamada S, Kurita H, Shimane T, Kamata T, Uehara S, Tanaka H
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: 45 Issue: 2 Pages: 147-152

    • DOI

      10.1016/j.ijom.2015.09.024

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 口腔扁平上皮癌ヨード不染域におけるグリコーゲン代謝経路内グルコース消費の検討2016

    • Author(s)
      相澤仁志、山田慎一、鎌田孝広、近藤英司、田中宏和、嶋根 哲、伊藤隆一、李 穎輝、栗田 浩
    • Organizer
      第54回日本癌治療学会学術集会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-10-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Use of glucose in glycogen metabolism in iodine non-stained (oraldysplastic/malignant) epithelium2016

    • Author(s)
      Yoshimura N, Kurita H, Li Y, Aizawa H
    • Organizer
      94th IADR General session
    • Place of Presentation
      Seoul、韓国
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Survival time analysis of oral cancer patients aged 75 years and older2015

    • Author(s)
      Kurita H,
    • Organizer
      22nd International Conference of Oral and Maxillofacial Surgery
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2015-10-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口腔扁平上皮癌におけるグリコーゲン代謝に関する検討2014

    • Author(s)
      相澤仁志、嶋根 哲、上原 忍、鎌田孝広、林 清永、寺本祐二、栗田 浩
    • Organizer
      第59回日本口腔外科学会総会
    • Place of Presentation
      幕張(千葉県)
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Vital Staining With Iodine Solution: Research of Glycogen Metabolism in Oral Squamous Cell Carcinoma2014

    • Author(s)
      Aizawa H, Shimane T, Qi F, Li Y, Xiao T, Kurita H
    • Organizer
      96th AOMS Annual Meeting, Scientific Sessions & Exhibition
    • Place of Presentation
      Honolulu(USA)
    • Year and Date
      2014-09-08 – 2014-09-13
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi