Analysis on glycogen metabolism in oral squamous cell carcinoma
| Project/Area Number |
26463040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Shinshu University |
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Principal Investigator |
KURITA Hiroshi 信州大学, 学術研究院医学系, 教授 (10273103)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | グリコーゲン / 口腔扁平上皮癌 / 代謝 / 解糖系 / グリコーゲン代謝 / 糖代謝 / ペントースリン酸経路 / 口腔癌 |
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| Outline of Final Research Achievements |
It is thought that the glycogen is one of key sources in supplying energy, nucleic acid, and lipid necessary for cancer cell proliferation in oral squamous cell carcinoma. The purpose of this study is to analyze metabolism of glycogen and to elucidate metabolism abnormality in oral squamous cell carcinoma. The results of this study suggested that oral squamous cell carcinoma cell got energy not simply in the glycolytic pathway, a simple course called the glycogen → glucose → glycolytic pathway, and they also suggested the possibility that oral squamous cell carcinoma might get energy by amino acid metabolism. It will be necessary to examine the metabolism of amino acid, glucuronic acid, and nucleic acids etc., and to analyze the specificity in the metabolism of oral squamous cell carcinoma.
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Report
(4 results)
Research Products
(6 results)
