| Project/Area Number |
26463041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
Kishimoto Koji 岡山大学, 医歯薬学総合研究科, 助教 (40243480)
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| Co-Investigator(Kenkyū-buntansha) |
伊原木 聰一郎 岡山大学, 医歯薬学総合研究科, 助教 (80549866)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIOKA Norie 岡山大学, 大学院医歯薬学総合研究科, 助教 (50362984)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | terrein / angiogenin / 口腔癌 / 血管新生作用 / 腫瘍増殖抑制作用 / 新規口腔癌治療薬 / angiogenin分泌抑制作用 / VEGF分泌抑制作用 / 腫瘍血管新生作用 / 口腔癌分子標的治療薬 / angiognein(ANG) / 分子標的治療薬 / 米国 |
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| Outline of Final Research Achievements |
This study assessed the effect of terrain, a bioactive fungal metabolite on oral cancer. Terrein inhibited angiogenin and VEGF secretions from oral cancer cells, both HSC-2 and SAS. Terrein also directly inhibited the proliferation both of the cancer cells. Furthermore, terrain inhibited a HSC-2 xenograft tumor growth in athymic mice through the inhibition of tumor cell proliferation and angiogenesis. These results suggest that terrein has a new lead compound for oral cancer therapy.
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