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Application of terrain glucoside, an inhibitor of angiogenin secretion as a new drug for oral cancer therapy

Research Project

Project/Area Number 26463041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

Kishimoto Koji  岡山大学, 医歯薬学総合研究科, 助教 (40243480)

Co-Investigator(Kenkyū-buntansha) 伊原木 聰一郎  岡山大学, 医歯薬学総合研究科, 助教 (80549866)
Co-Investigator(Renkei-kenkyūsha) YOSHIOKA Norie  岡山大学, 大学院医歯薬学総合研究科, 助教 (50362984)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsterrein / angiogenin / 口腔癌 / 血管新生作用 / 腫瘍増殖抑制作用 / 新規口腔癌治療薬 / angiogenin分泌抑制作用 / VEGF分泌抑制作用 / 腫瘍血管新生作用 / 口腔癌分子標的治療薬 / angiognein(ANG) / 分子標的治療薬 / 米国
Outline of Final Research Achievements

This study assessed the effect of terrain, a bioactive fungal metabolite on oral cancer. Terrein inhibited angiogenin and VEGF secretions from oral cancer cells, both HSC-2 and SAS. Terrein also directly inhibited the proliferation both of the cancer cells. Furthermore, terrain inhibited a HSC-2 xenograft tumor growth in athymic mice through the inhibition of tumor cell proliferation and angiogenesis. These results suggest that terrein has a new lead compound for oral cancer therapy.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2014 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (1 results)

  • [Int'l Joint Research] タフツ大学分子腫瘍研究所(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production.2016

    • Author(s)
      Shibata A, Ibaragi S, Mandai H, Tsumur a T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 2161-2168

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] ANGIOGENIN IS A MOLECULAR TARGET FOR ORAL CANCER DRUG DEVELOPMENT2014

    • Author(s)
      K. Kishimoto, S. Yoshida, S. Ibaragi, N. Yoshioka, A. Shibata, A. Sasaki
    • Organizer
      22 Congress of the European Association for Cranio-Maxillo- Facial Surgery
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2014-09-22 – 2014-09-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-02-16  

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