Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
We studied for the purpose of clarifying the details of the mechanism of EMT which gave to the acquisition of high invasive ability of oral squamous cell carcinoma that Metadherin (MTDH) which we found induced.We investigated in detail a cell motility, an overexpression of the substrate degrading enzyme and a decreased expression of cell adhesion factor we have researched and examined ever.These results suggest that MTDH may relate with the acquisition of high infiltration ability of the oral squamous cell carcinoma cell.In addition, it was suggested that the acquisition of infilitration ability can relate to the acquisition of the stem cell-like form closely.
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