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Expression and role of cancer stem cell marker in invasion and metastasis of oral cancer

Research Project

Project/Area Number 26463050
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionKagoshima University

Principal Investigator

ISHIDA Takayuki  鹿児島大学, 医歯学域附属病院, 助教 (20404501)

Co-Investigator(Kenkyū-buntansha) 吉村 卓也  鹿児島大学, 医歯学域附属病院, 助教 (30726758)
中村 典史  鹿児島大学, 医歯学域歯学系, 教授 (60217875)
久米 健一  鹿児島大学, 医歯学域附属病院, 助教 (60650067)
比地岡 浩志  鹿児島大学, 医歯学域附属病院, 講師 (70305150)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsがん幹細胞 / 口腔扁平上皮癌 / 浸潤能 / 転移能 / 口腔癌 / 癌幹細胞 / EMT / 幹細胞マーカー / 転移
Outline of Final Research Achievements

Cancer stem cells are attracting attention as a factor showing chemoradiotherapy resistance of cancer tissue, but in recent years cancer cells have acquired cancer stem cell-like properties by causing epithelial mesenchymal transition (EMT). It is pointed out that the metastatic potential may be enhanced. We induced EMT by introducing snail into oral cancer cell line HSC4 and confirmed that the expression level of mRNA of stem cell markers in the cell line increases. These findings suggested that induction of EMT in oral cancer cell lines would acquire cancer stem cell-like properties.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (7 results)

  • [Journal Article] A diagnosis system for detecting cervical lymph node metastasis in oral squamous cell carcinoma: Collective consideration of the results of multiple imaging modalities2017

    • Author(s)
      Takayuki Ishida, Hiroshi Hijioka, Kenichi Kume, Takuya Yoshimura, Akihiko Miyawaki, Etsuro Nozoe, Shigeaki Suenaga, Hiroko Indo, Hideyuki J. Majima, Norifumi Nakamura
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 29 Issue: 3 Pages: 210-216

    • DOI

      10.1016/j.ajoms.2016.12.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A diagnosis system for detecting cervical lymph node metastasis in oral squamous cell carcinoma: Collective consideration of the results of multiple imaging modalities.2017

    • Author(s)
      Takayuki Ishida, Hiroshi Hijioka, Kenichi Kume, Takuya Yoshimura, Akihiko MIyawaki, Etsuro Nozoe, Shigeaki Suenaga, Hiroko Indo, Hideyuki J. Majima, Norifumi Nakamura.
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 5 Pages: 210-216

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cystadenocarcinoma of the minor salivary gland arising in the upper lip: A surgical case of an inadequate cytology specimen hampering conclusive diagnosis.2016

    • Author(s)
      Yoshimura T, Yamada S, Ishida T, Tanaka K, Kitazono I, Kume K, Hijioka H, Semba I, Nakamura N, Tanimoto A
    • Journal Title

      Human Pathology: Case Reports

      Volume: ー

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 口腔扁平上皮癌症例におけるリンパ節転移予測因子としてのbudding scoreの有用性の評価2018

    • Author(s)
      石田喬之、比地岡浩志、宮脇昭彦、嶋 香織、久米健一、品川憲穂、本庄希江、野村綾子、野添悦郎、仙波伊知郎、中村典史
    • Organizer
      第36回日本口腔腫瘍学会総会・学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 舌扁平上皮癌 T1・T2症例における頸部リンパ節転移予測因子の検討2017

    • Author(s)
      石田 喬之 、比地岡 浩志、宮脇 昭彦、末永 重明、嶋 香織 、久米 健 一、品川 憲穂、 本庄 希江、野添 悦郎、馬嶋 秀行、仙波 伊知郎、中村 典史
    • Organizer
      第35回日本口腔腫瘍学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 左側全頸部郭清後に乳糜胸をきたした1例2017

    • Author(s)
      後藤 雄一 、今村 晴幸、坂元 亮一、石田 喬之 、松村 吉晃、別府 真広、杉浦 剛
    • Organizer
      第35回日本口腔腫瘍学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2017-01-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 当科における口腔扁平上皮癌の臨床統計学的検討2016

    • Author(s)
      石田喬之、比地岡浩志、吉村卓也、久米健一、野添悦郎、中村典史
    • Organizer
      第34回日本口腔腫瘍学会総会
    • Place of Presentation
      横浜市開港記念会館(神奈川県横浜市)
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔扁平上皮癌における肩甲舌骨筋上頸部郭清術の臨床的検討2015

    • Author(s)
      比地岡浩志、石田喬之、久米健一、吉村卓也、野添悦郎、中村典史
    • Organizer
      第60回日本口腔外科学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 口腔白板症における臨床像と病理組織診断の検討2015

    • Author(s)
      吉村卓也、比地岡浩志、石田喬之、久米健一、野添悦郎、中村典史
    • Organizer
      九州地区口腔癌研究会第19回学術講演会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 乳癌におけるPCP4/PEP19の浸潤転移への関与2015

    • Author(s)
      吉村卓也、比地岡浩志、石田喬之、久米健一、中村典史
    • Organizer
      第69回日本口腔科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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